Effect Of TongfuXiere Recipe On Procalcitonin And Immune Function Of Patients With Surgical Sepsis

[Objective] Sepsis is often accompanied by some complications of surgical critical illness, sucn as severe infection, severe trauma, severe acute abdomen and after major surgery; is also the important reasons of induceing septic shock and multiple organ dysfunction syndrome (MODS). Epidemiology shows that the incidence of sepsis was rising in recent years and the high mortality rate did not fall, this has constituted a serious threa on human health. Although the understanding and diagnosis and treatment of sepsis has made much progress, but the effects are not exact, and integrated traditional Chinese and western medicine is an important measure for treatment of sepsis. Integrated traditional Chinese and western medicine emphasize chinese medicine diagnosis and treatment combine with microscopic pathological changes, when in the treatment of sepsis, flexible processing for the treatment of sepsis to provide a new way. This article is in the western conventional treatment methods, cooperate to use TongfuXiere Recipe to treat patients with sepsis showing intestinal organs real hot and Warm internal filled. To explore the impact of surgical patients with sepsis on procalcitonin levels of the side of the peripheral blood, immune function, postoperative complications (early intestinal obstruction, respiratory tract infections, wound infections, MODS). For TongfuXiere Recipe could be applied in surgical treatment of sepsis provide the basis.[Method] The objects come from the Stomach and Intestine and Thyroid Surgical Department, the Liver and Gall Surgical Department, ICU and other hospital departments. in The First Affiliated Hospital of Guangzhou University of TCM, during January 2010 and December 2010. We use the method of randomized control trial(RCT) to make treatment group and control group 30 patients separately, and the two groups have no obvious difference. Two groups were given western conventional treatment of sepsis, The treatment group is based on western conventional treatment, giving Chinese medicine TongfuXiere Recipe for treatment, the control group is based on western conventional treatment, giving saline treatment for treatment. Determine Procalcitonin, T lymphocyte subsets (CD3+,CD4+,CD8+) and CD14+monocyte human leukocyte antigen DR(HLA-DR /CD14+) in the side of peripheral blood of both groups of patients, before and after treatment 1,3,7,14 days. Observe postoperative obstruction, respiratory infections and wound infection, MODS etc complications, also observe length of hospitalization.[Result] Treatment group and control group PCT after treatment were reduced, CD3+,CD4+,CD8+,CD4+/CD8+,HLA-DR/CD14+are elevated, But compared with controls, the treatment group 3,7 days PCT reduced significantly (P<0.01), CD3+, CD3+,CD4+,CD8+,CD4+/CD8,HLA-DR/CD14+7,14 days rise significantly (P<0.01), and 3days rise no significant difference (P>0.05); The complication rate of Intestinal obstruction, wound infection, respiratory infections and MODS reduced significantly (P<0.01); hospital stay also have shortened (P<0.01). [Conclusion] TongfuXiere Recipe can reduce the level of procalcitonin in Patients with surgical sepsis, Improve immune function, attenuate the systemicinflammatory response and recuperate immune; reduce the incidence ofcomplications, Prevent MODS happen, thereby reducing mortality, but also shorten hospital stay.