| ObjectiveThe randomized controlled trials were performed, subcutaneous space was created in guinea pigs with normal or abnormal coagulation state and different doses of AristaTM absorbable hemostat (AH) were applied for the healing effect. This study aims to provide theoritical basis and to assess the specified amount of AristaTM AH used during surgery.MethodModels of coagulation dysfunction were established by providing guinea pigs intravenous injection of heparin sodium solution. The guinea pigs were randomly divided into control group, and two other groups with 0.5g and 1.0g AristaTM AH application, respectively. A subcutansous space were created in each animal. The guinea pigs were observed in general and skin graft survival 9 days post surgery. Specimen were obtained for HE staining and CD-31 immuno-staining. Positive units (PU) were measured to investigate the healing of subcutaneous space and the effectiveness of AristaTM AH.Results1. General:The guinea pigs survived after all, no one patients had died; part of the guinea pig infection cases, self-healing; weight were slightly reduced, to reduce by about 10～20g; no other special exceptions occurred.2. Coagulopathy 1.0g under which the amount of skin graft survival group was significantly lower than the other two groups resulted in statistically significant (P<0.05).0.5g normal coagulation state the amount of skin graft survival group than other groups, the result was statistically significant (P |
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