| Objective: To evaluate the efficacy of new methods(Namely: poor blood supply of liver cancer were treated with balloon catheter to temporarily block the main artery, and then pressurized infusion chemotherapy and embolization)of the interventional according to lipiodol aggregation, dual-path changes in the tumor and tumor volume changes by CT technology, and evaluate the value of the CT in the intervention in liver cancer. And compare the difference between aspects of method and the semi-automatic in measurment of tumor volume.Materials and Methods: 120 patients with poor blood supply of primary liver cancer patients require interventional therapy as the research object, 60 patients in experimental group and control group respectively, experimental group were involved in the introduction of new methods of treatment, the control group were treated with traditional methods of intervention, all patients were randomized into groups for the experimental group and control group.The maximum diameter of lesions combined 3cm15cm range, number of lesions≤5. All the patients did CT examination before intervention and in 1.5 months ,3 months, 6 months, 12 months after the intervention, CT observed lipiodol situation filling within the tumor, simultaneous measureed the size and the volume of tumor (using the mouse to delineate the tumor contours layer by layer or every few layers, the area of tumor volume was measured by the computer software).Results: Evaluation the effect of the new intervention method based on lipiodol aggregation , the experimental group after enrollment in 1.5 months, 3 months, 6 months, 12 months of clinical efficacy rates were: 58.82%, 73.68%, 41.67%, 50%; clinical benefit rates were: 94.12%, 100%, 100%, 100%. Control group after enrollment in 1.5 months, 3 months, 6 months, 12 months of clinical efficacy rates were: 51.72%, 38.46%, 37.5%, 25%, clinical benefit rates were: 89.66%, 92.31% 100%, 75%.According to WHO criteria and RECIST criteria to evaluate the efficacy of new method of intervention, the experimental group in 1.5 months, 3 months, 6 months, 12 months after enrollment of clinical efficacy rates were: 21.05%, 29.41% ,53.85%, 42.86% ; 13.61%, 17.65%, 53.85%, 42.86%. Clinical benefit rates were: 84.21%, 82.35%, 84.62%, 57.14%; 92.11%, 76.47%, 92.31%, 71.43%. Control group after enrollment in 1.5 months, 3 months, 6 months, 12 months of clinical efficacy rates were: 14.71%, 41.18%, 52.94%, 66.67%; 8.82%, 41.18%, 47.06%, 44.44%. Clinical benefit rates were: 76.47%, 76.47%, 82.35%, 88.89%; 85.29%, 94.12%, 88.24%, 88.89%. Comparing the results of two efficacy evaluation, P values of experimental group in 1.5 months, 3 months, 6 months, 12 months after enrollment were: 0.307,0.706,0.801,0.766; the control group in 1.5months, 3 months, 6 months, 12 months after enrollment respectively were: 0.422,0.494,0.894,0.721, P values were> 0.05, no significant between the two is different (P> 0.05).Evaluation the effect of the new intervention method based on tumor volume,the experimental group after enrollment in 1.5 months, 3 months, 6 months, 12 months, the percentage of tumor volume were reduced: 64.29%, 70.59%, 57.14%, 25%. Control group after enrollment in 1.5 months, 3 months, 6 months, 12 months, reduced the percentage of tumor volume were as follows: 57.14%, 56.25%, 40%, 25%. Comparative aspects of method and the semi-automatic measurement of tumor volume, the two methods was not significant (P = 0.436, P> 0.05) before into the group, after enrollment in 1.5 months, 3 months, 6 months, 12 months, the two methods still no statistically significant (P values were: 0.260,0.575,0.839,0.857, P> 0.05).Conclusion: To evaluate the efficacy of new methods of the interventional according to lipiodol aggregation, dual-path changes in the tumor and tumor volume changes by CT technology, experimental group was better than the control group, that is, compared to traditional methods, the new method has a certain effect. Semi-automatic measurement of tumor volume is simple, less time consuming than the aspect method which is the preferred method of measuring tumor volume. A RECIST criterion than the WHO standard is simple, easy to operate, is a worthwhile clinical evaluation of solid tumors to promote the implementation of the new standards. Comprehensive use of CT technology and combination of several methods involved in evaluating interventional efficacy can be used for the reference for interventional therapy evaluation and intervention if needed further treatment. Objective: To evaluate the value of MRI DWI in the efficacy of intervention in the liver cancer.Materials and Methods: 120 patients with poor blood supply of primary liver cancer patients require interventional therapy as the research object, 60 patients in experimental group and control group respectively, experimental group were involved in the introduction of new methods of treatment, the control group were treated with traditional methods of intervention, all patients were randomized into groups for the experimental group and control group.The maximum diameter of lesions combined 3cm15cm range, number of lesions≤5. All patients did MRI DWI examination befor intervention.ADC values of lesions were measured to identify whether it is the poor blood supply of live cancer.All the patients did MRI DWI examination in 1.5 months,3 months, 6 months, 12 months after the intervention,to observe the degree of tumor necrosis, lesions were measured ADC value simultaneously, according to ADC values measured in DWI images and analyzed statistically.Results: All lesions showed low signal in the MRI T1WI, the lesion showed high signal in MRI T2WI.Dynamic contrast-enhanced scans:At arterial phase all lesions were not obviously enhanced and enhancement of no noticeable at portal phase and delayed phase.All lesions on DWI showed high signal.b = 600 sec/mm2, the mean ADC value of lesions was (1.54±0.40)×10-3mm2 / s, the average ADC value of the surrounding liver tissue was (1.73±0.46)×10-3mm2 / s, the difference between the two statistically significant (P = 0.002, P <0.05); b = 800 sec/mm2, the average ADC value of lesions was (1.43±0.39)×10-3mm2 / s, around the average ADC value of liver tissue was (1.58±0.36)×10-3 mm2 / s, the difference between the two was statistically significant (P = 0.011, P <0.05).And survival of tumor tissue and necrosis tissues clearly displayed on the DWI, the signal was significantly different. b = 600sec/mm2 the average ADC value of tumor necrosis was(1.86±0.21)×10-3mm2 / s, the average ADC value of survival tumor tissue was (1.42±0.17)×10-3mm2 / s, the difference between the two was significance (P = 0.000, P <0.05); b = 800sec/mm2 the average ADC value of tumor necrosis was (1.88±0.33)×10-3mm2 / s, the average ADC value of survival tumor tissue was (1.34±0.26)×10-3mm2 / s, ADC values of tumor necrosis was significantly higher than the survival of tumor tissue, the difference between the two was statistically significant (P = 0.001, P <0.05).Comparison of the experimental group and control group in 1.5 months after enrollment, b = 600sec/mm2 in experimental group, the average ADC values was (1.63±0.64)×10-3mm2 / s, the average ADC values of the control group was (1.81±0.66)×10-3mm2 / s, the difference between the two was not significant (P = 0.600, P> 0.05); b = 800sec/mm2 in the experiment group, the average ADC values was (1.55±0.80)×10-3mm2 / s, the average ADC value of the control group was (1.70±0.65)×10-3mm2 / s, the difference between the two was not significant (P = 0.710, P> 0.05). Comparison of the experimental group and control group in 3 months after enrollment , b = 600sec/mm2 in experimental group, the average ADC values was (1.58±0.31)×10-3mm2 / s, the average ADC values of the control group was (1.76±0.72)×10-3mm2 / S, the difference between the two was not significant (P = 0.596, P> 0.05); b = 800sec/mm2 in the experiment group, the average ADC values was (1.50±0.09)×10-3mm2 / s, the average ADC Value of the control group was (1.91±0.63)×10-3mm2 / s, the difference between the two was not significant (P = 0.132, P> 0.05).Conclusion: Experimental group and control group in 1.5 months and 3 months after enrollment had no significant statistically values (P> 0.05). MRI DWI can be used as diagnosis bofore intervention in poor blood supply liver cancer patients, also can evaluate the efficacy of interventional treatment to determine tumor recurrence or not and judge the degree of necrosis of the tumor,to spply further treatment in order to provide for the clinical program. Objective: TO disscuss the relationship of liver volume in different Child-Pugh classification and liver function, and to compare the liver volume change between the experimental group and control group ,and the difference between aspects of method and the semi-automatic in measurment of liver volume.Materials and Methods: 120 patients with poor blood supply of primary liver cancer patients require interventional therapy as the research object, 60 patients in experimental group and control group respectively, experimental group were involved in the introduction of new methods of treatment, the control group were treated with traditional methods of intervention, all patients were randomized into groups for the experimental group and control group. the maximum diameter of lesions combined 3cm15cm range, number of lesions≤5.CT examination did before the intervention, measured the size of liver volume simultaneously(using the mouse to delineate the liver contours layer by layer or every few layers, the area of non-tumor liver volume size was measured by the computer software), and classified patients with Child-Pugh.All the patients did CT examination in 1.5 months,3 months, 6 months, 12 months after the intervention,to measure the size of liver volume,and classified patients with Child-Pugh again, simultaneous measure the volume of liver,according to Child-Pugh classification and the measured liver volume were analyzed statistically.Results: 92 patients in Child-PughA grade, 20 patients in Child-PughB grade.The average liver volume of Child-PughA level was: 1301.56±265.39cm3, the average liver volume of Child-PughB level was: 988.64±109.05cm3, the average liver volume of Child-PughA level was greater than the Child-PughB, the liver function of Child-PughA was better than the Child-PughB.The liver volume between Child-PughA and Child-PughB was statistically significant difference (P = 0.000, P <0.05). Measuring the liver volume of experimental group and control group in Child-PughA level, the average volume of the liver in experimental group before intervention and in 1.5 months , 3 months, 6 months, 12 months after the intervention were: 1306.99±322.48cm3, 1199.37±192.43cm3, 1460.11±321.44cm3, 1360.80±250.17cm3; the average volume of the liver in control group before intervention and in 1.5 months , 3 months, 6 months, 12 months after the intervention were:1259.86±261.70cm3, 1259.53±219.85cm3, 1455.53±136.53cm3, 1571.82± 250.23cm3. The liver volume in the experimental group and control group before intervention was not significant (P = 0.633, P> 0.05), and still had no significant in 1.5 months , 3 months, 6 months, 12 months after the intervention (the values of P were: 0.387,0.985,0.272, P> 0.05). Aspects of method and the semi-automatic measurement of tumor volume were used to measure liver volume was not significant (P = 0.895, P> 0.05) before the enrollment, there was still no statistically significant measurement of liver volume (P values were: 0.527,0.242,0.155,0.642, P> 0.05) in 1.5 months, 3 months, 6 months, 12 months after the intervention.Conclusion: Liver volume does reflect liver reserves, which is an important indicator.Combine liver volume and child classification will facilitate the proper assessment of liver functional reserve. There is no significant difference between experimental group and control group in liver volume.Semi-automatic measurement of liver volume is simple, less time consuming than the aspect method which is the preferred method of measuring liver volume.
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