| Objective:To figure out if there are any changes on the P300 of the children with learning disability and the degree and features of these changes. To study the effect of the intervention in children with LD on the changes of the event-related potential P300.To explore the value in evaluating the cognitive function in children with learning disability.Method:The group of 59 children with learning disability aged 6-10 years were diagnosed by ICD10 LD diagnostic criteria, Wechsler Intelligence Scale scores and grades. The control group of 40 normal children aged 6-10 years were from ordinary primary schools. All children's Wechsler scale (WISC-R) total IQ (FIQ) scores were> 70 points. All children were tested by P300. The group of children with LD had appropriate intervention. The two groups of children were retested by P300 after 3 months.Result:(1)Analyze the P300 between the LD group and the control group The latencies of P2,N2,P3 were significantly longer in the children with LD than in the control group, all P values were<0.05.The latencies (ms) of P2,N2,P3 were 173.962±31.106,227.461±33.390, 325.035±33.073 in the LD group, and 159.175±28.968,210.860±25.408,298.068±18.933 in the control group. The amplitude of P3 in the children with LD was significantly smaller than that in the control group, P<0.05. The amplitude (uV) of the LD group was 8.187±4.867, that of the control group was 10.319±4.722.(2) P300 Comparison of two groups before and after 3monthThe latency (ms) of P2,N2,P3 were 152.488±27.249, 207.644±27.659,291.713±30.883 after intervention in LD group.They were significantly shorter than before, P<0.01. The amplitude (uV) of P3 retest in children with LD after intervention was 8.514±5.188, the difference was no statistically significant between before and after intervention, P>0.05. After 3 months in the control group,the latencies (ms)of P2, N2, P3 were 154.385±23.771,200.738±26.439,297.950±17.652,and the amplitude of P3 (uV) was 10.020±5.748.The difference were not statistically significant, P>0.05.Conclusion:There is long latency, low amplitude wave in children with LD, brain cognitive dysfunction exists. Event-related brain potentials P300 may evaluate LD children's cognitive function. Objective:To study the PRVEP characteristics of children with learning disability. To explore the value of P100 on brain cognitive function in children with learning disability.Methods:The group of 42 children with learning disability aged 6-10 years were diagnosed by ICD10 LD diagnostic criteria, Wechsler Intelligence Scale scores and grades. The control group of 37 normal children aged 6-10 years were from ordinary primary schools. They were evaluated using the Wechsler Intelligence Scale and recorded PRVEP at five levels of spatial frequency (checkerboard pattern (check) sizes of 108',54',27',13'and 7'). We recorded and analyzed stimulation latency and amplitude of P100 wave.Results:1. At the five different spatial frequencies from low frequency to high spatial frequency, the two groups children were evoked the P100 wave. As spatial frequency increases, the latencies of the two groups of children were extended. In the control group, the latency (ms) of P100 were 101.297±4.179,102.426±4.030,103.601±5.291,109.655±6.884, 118.635±6.679; in LD group, the latency (ms) of P100 were 102.857±4.182,103.816±4.284,107.018±6.297,113.464±9.291,125.226± 11.676. In the meanwhile, with the spatial frequency increases, the amplitudes of P100 in the two groups of children were reduced. The amplitudes (uV) were 20.208±8.539,18.939±7.457,17.731±8.902,16.225±9.214,12.282±7.334 in the control group. The amplitudes (uV) of P100 wave were 18.965±8.169,17.286±7.713,14.164±8.299,12.901±9.881,9.213±6.818 in LD group.2. The latencies of P100 wave were significantly prolonged at all five spatial frequency in the LD group compared with the control group, P <0.05. The amplitudes of P100 were no significant difference between the two groups at 108',54'two spatial frequency, P>0.05. But the amplitudes of P100 in the LD group were significant smaller than that in the control group at the 27',13',three spatial frequency, P<0.05.Conclusion1. The latency of P100 wave increased and the amplitude of P100 wave decreased gradually with the extension of spatial frequency.The ability to process information differently at the different spatial frequencies.2. The latencies of P100 wave were longer in LD group than that in control group at all 5 different spatial frequencies. The P100 amplitudes were smaller in the children with LD than in the normal children at the high spatial frequency.It is indicated that the transmission function of retinal ganglion cells to the visual center deal difficultly in the children with LD and the visual information processing speed slow down.3. The P100 wave of PRVEP can be used as a clinical evaluation of cognitive function in the visual physiological indicators in children with LD. |
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