The Experimental Study Of Qihong Decoction On The Effects In Rat Model With Isoproterenol Induced Chronic Heart Failure

Objective:To study the treatment of Qihong Decoction in rat model with isoproterenol induced chronic heart failure and to observe the effects on brain natriuretic peptide (BNP) and matrix metalloproteinase-9 (MMP-9) and to explore the mechanism of its prevention and treatment of heart failure. Methods:The method of subcutaneous injection of isoproterenol copy cardiac failure model, determination of cardiac function after 6 weeks that model successful, will become the model rats were randomly divided into model group, low dose of Qihong decoction, Qi Hong granule middle dose group high dose of Qihong decoction and digoxin group, were administered again after 4 weeks, cardiac function measured using the enzyme immunoassay of serum BNP, MMP-9 levels, and take heart tissue that re-recording, calculating the heart weight index of treatment, morphological features of cardiac pathology. Results:â‘ compared with blank control group, the model group declined in cardiac function,LVEDD,LVESD increased and EF,FS decreased. Every treatment groups significantly improved cardiac function after 4 weeks, LVEDD,LVESD decreased and FS,EF increased.â‘¡compared with blank control group, heart weight index was ignificantly increased among model group, Qi Hong low dose group and digoxin group, while Qi Hong granule medium-dose and high-dose were no significant difference (P> 0.05); Compared with model group, the treatment groups of heart weight and heart weight index decreased, there was significant statistical difference (P<0.01).â‘¢Compared with blank control group, the content of BNP, MMP-9 increased significantly in model group (P<0.01); compared with model group, the content of BNP, MMP-9 decreased in every treatment group (P<0.01), Qi Hong granule which high, medium dose group were obviously better than that of digoxin group (P<0.01), Qi Hong granule low-dose compared with digoxin group no significant difference (P> 0.05).Conclusion:Qihong decoction can significantly alleviate symptoms, improve heart function, regulating cardiac endocrine function in the heart and reverse ventricular remodeling.