Clinical Analysis Of 145 Patients With Psoriasis And Questionnaire Survey Of Life Quality Of 68 Cases Of Vulgaris Psoriasis

ObjectiveTo evaluate clinical characteristics, mainly focused on various associated risk factors and life quality of patients with psoriasis in Zhejiang Province, to provide the basis of clinical early intervention, improvement of living quality and improvement of the living quality and enhancing comprehensive treatment effectMethodsIn 145 cases of patients with psoriasis treated at First affiliated hospital from December 2009 to March 2011, their clinical features and treatment were evaluated by questionnaire survey. Life quality evaluation and survey were performed with the questionnaire of dermatology life quality index (DLQI) in 68 cases of vulgaris psoriasis.ResultsIn 145 cases of psoriasis, male:female ratio is1.64:1.0. For the male and female patients, the peak ages of the first onset distributed from 20 to 40 years, and the average ages were 30.62 and 27.57 years respectively.15.1% cases reported to have a family history, in which differences were not statistically significance (p>0.05). However, family history factor was statistically associated with longer clinical course and poorer therapy response (P<0.05). Survey showed the commonest factor related to inducing psoriasis was inheritance, secondary factors including stress, infection, trauma or surgery, drinking alcohol, smoking and female production. Climate, drinking alcohol, stress, streptococcal infection of the throat and diet were associated with the disease progression. In vulgaris psoriasis,20 cases of disease progression resulted from throat infection accounted for 15.6%, while 41.2% in non-vulgaris type of psoriasis. The differences between them was statistically significance (X2=6.466, p=0.019).87% of patients with psoriasis complained cutaneous pruritus, mainly on mild and intermediate extent. Pruritus degree subjectively was statistically associated with skin injury area and PASI scoring (p<0.05).Psoriasis patients with nail injury accounted for 46.8%, which nail lesions manifested pitting, splinter, subungual hyperkeratosis and onycholysis. The patients with nail injury had longer diseased course (mean 179.96 months) than that without it (mean 71.16 months), which the difference was statistically significance (t=5.48,p=0.00). Psoriasis patients had usually systemic disease manifestations such as hypertension (19.4%), hyperlipemia (12.9%), diabetes (10%), autoimmune disease(5%) and malignancies (2.7%). Most subscales of the DLQI have significant difference between patients with psoriasis and controls.ConclusionsMale psoriasis morbidity was higher than the female in Zhejiang province; Psoriasis patients with family history had longer diseased course; Psoriasis is a systemic disease, more common systemic diseases including hypertension, hyperlipemia, diabetes, autoimmune disorder and malignancies; Psoriasis patients had decreased immune competence resulting in higher occurrence of subscales...