Human Hepatocellular Carcinoma With Expression Of Peroxisome Proliferator-activated Receptor γ (PPAR-γ) In HBV-Related And HCV-Related Infections

Objective:To investigate the different expression of peroxisome proliferator-activated receptor-gamma in Human Hepatocellular Carcinoma tissues and the corresponding adjacent nontumoral liver tissues with HBV-Related and HCV-Related infections.Methods:Collect 40 cases of Hepatocellular Carcinoma tissues and the correspo-nding adjacent nontumoral liver tissues with HBV-Related infection,16 cases of Hepatocellular Carcinoma tissues and the corresponding adjacent nontumoral liver tissues with HCV-Related infection which were treated by surgical resecting and had complete clinicopathological informations from October 2008 to September 2010 in Hunan Provincial People's Hospital and The Second Xiangya Hospital of Central South University and The First Affiliated Hospital of Nanhua University. Detect the expression of PPAR-gamma in the cases of Hepatocellular Carcinoma tissues and the corresponding adjacent nontumoral liver tissues with HBV-Related and HCV-Related infections by immunohistochemistry, And make a quantitative analysis of the expression of PPAR-gamma by accessing their mean gray scale with Motic Image Advanced 3.2 color imaging analysis system,then analyse the relationship between PPAR-gamma and the clinicopathological informations.Results:The mean gray scale of HCC tissues and the corresponding adjacent nontumoral liver tissues with HBV-Related infection were respectively 91.13±3.28 and 114.18±3.27, the mean gray scale of HCC tissues and the corresponding adjacent nontumoral liver tissues with HCV-Related infection were respectively 99.75±4.99 and 117.69±4.91,the differences between them are very significant(P<0.05).The express degree of PPAR-gamma in HCC tissues was not associated with sex,age,tumor size,serum AFP levels,tumor embolus of portal vein or vena cana(P> 0.05),but with differentiation degree and hepatitis virus infection(P<0.05).Conclusions:1.The expression of PPAR-gamma in HCC tissues with HBV-Related and HCV-Related infections is higher than their corresponding adjacent nontumoral liver tissues.2. The expression of PPAR-gamma in poor-differentiated HCC is higher than its in well-differentiated HCC. Detection of PPAR-gamma is valuable for evaluating malignancy extent.3. PPAR-gamma may involve in the development of HCC with HBV-Related and HCV-Related infections.It may be one of the influencing factors which lead to HCC with HBV-Related infection having a high incidence and a fast progress than HCC with HCV-Related infection.