The Research On Treating The Breast Hyperplasia Rats With The Huiyang-YuLong Cream Combining Treatment Of The Magnetic And The Hyperthermia

Objective: Explore Hui YangYuLong anointed joint magnetic therapy, back to thermotherapy female SD rats hyperplasia of mammary gland organization and sex hormone levels, liver, kidney and myocardial cell influence, provides the theory basis for clinical trials.Methods:Take SD female rats (virgin mice) 40, rat hind limb medial intramuscular injection of estradiol benzoate 0.5mg/kg, 1 times / day for 25 days, continued with progesterone 5mg/kg intramuscularly, 1 / Day for 5 days, a total of 30 days. 5 rats were killed by pathological examination confirmed successful model. Rat mammary diameter and height measurements, the rats were randomly divided into five groups of more than. N = 7, respectively, A group: matched group; B group: Chinese medicine; C group: magnetic group; D groups: hyperthermia group; E Group: magnetic, thermal, drug combination group. Group A with only the mammary gland treatment garment package, group B with Hui YangYuLong ointment, 24 hours/days, A total of 30 days. Group C: use static magnetic magnets, magnetic therapy group for 6 mT to the magnetic field strength 9mT, every time 30 minutes/days, 15 days for one period of treatment, a total of 2 treatment or 30 days. Group D: use warm ReTie heat, illuminate bilateral breast, illuminate℃, the highest temperature average 39 for 45℃, five hours later take down ReTie, a total of 30 days. Group E: by HuiYangYuLong anointed joint magnets, hyperthermia, every 30 minutes remove magnets, five hours later take down ReTie, retain Chinese medicine 24 hours, a total of 30 days. Article 31 days measurement rats diameter and height of mammary gland, cut off after the second to mammary gland do pathology testing, and the heart, blood test each animal liver, kidney function, estradiol (E2), progesterone (P), prolactin (PRL) level, in another rat cardiac and mammary gland do pathology testing, observe the rat breast-duct changes.Results:(1) using benzoic acid oestrogen and progesterone build mammary gland hyperplasia model success rate can amount to 100 %.(2) and group A comparative B, C, D, E exp1, rats breast height and diameter decreased, and with significant difference (P <0.05). Group E and B, C, D compared each rat breast height and diameter also have decreased, and with significant difference (P < 0.05). B,C,D, each group has no obvious comparative differences significant(P>0.05)(3) A, B, C, D, E compare each group of liver, kidney no significant changes (P >0.05).(4) and group A comparative B, C, D, E exp1, estradiol (E2), prolactin (PRL) decline, progesterone (P) water Flat to rise, but with significant difference (P <0.05). Group E and B, C, D each comparison, estradiol (E2), Prolactin (PRL) drop more apparent, progesterone (P) leels, and with significant difference (P <0.05). B,C,D, each group has no obvious comparative differences significant(P>0.05).(5) with A group of comparative B, C, D, E exp1 acini, reducing the number of acinus cavity diameter narrowing, group E and B, C, D each comparison acinar reducing the number is more apparent, acinus cavity diameter narrowing the more obvious.(6) A, B, C, D, E each group compared myocardial cell no change.Conclusion:(1) female SD rats intramuscular benzoic acid estradiol while establishing joint progestin female SD rats mammary gland hyperplasia model is effective.(2) Chinese medicine, magnets, hyperthermia for hyperplasia of mammary gland rats are treatment function. Chinese medicine combined magnetic therapy, thermotherapy to hyperplasia of mammary gland rats therapeutic effect of TCM, magnetic therapy and better results than those heat therapy. Alone in the Chinese traditional medicine, magnetic therapy and heat therapy in treating effect no obvious difference.(3) medicine, magnetic therapy, heat treatment, as well as Chinese native medicine combined magnetic, hyperthermia for female SD rat is relatively safe.