Multivariate Regression Analysis Of Posthepatectomy Liver Failure Of Resection Of Big Hepatocellular Carcinoma In Elderly Patients

Object:To study rick factors associated with posthepatectomy liver failure of big hepatocellular carcinoma in elderly people.Methods:Collected 109 cases of elderly people who had accepted resection of heptocellular carcinoma those were testified as primary big heptocellular carcinoma(the diameter of single nodular tumor>5cm,≤10cm) between Feb 2006 and Oct 2010 at Xiangya second hosppital of central south university。And single variant and multivariate stepwise regression model were used to analysis the factors associated with postoperative complications such as Child-Pugh classification,liver cirrrhosis and so on.Results:The overall morbidity of liver failure is 50.4%,and mortality is 4.59%.Single variant analysis showed that the Child-Pugh classification,prealbumin(PEA),totla bilirubin (TBIL),intraoperative blood loss and blood trasfusion,time of hepatic portal occlusion,rest liver volume/entire lliver volume(RLV/ELV) were associated with posthepatectomy liver failure of big hepatocellular carcinoma in elderly patients.Furthermore,multivariate stepwise regression analysis revealed that Child-Pugh classification, time of hepatic portal occlusion and intraoperative blood transfusion were the independent risk factors of morbidity of resection of hepatocellular carcinoma in elderly patients. Conclusion:Child-Pugh classification, time of hepatic portal occlusion and intraoperative blood transfusion are the most important risk factors associated with posthepatectomy liver failure of big heptocellular carcinoma in elderly patients.And the keys to decrease the morbidity of liver failure are preoperative synthesized evaluation and proper intraoperative selection of operative approach.