An Epidemiologic Investigation On Chronic Constipation And Its Associated Pathogenetic Factors In Part Of The Health Cheke-crowd In Hefei Area

Background & purpose: Chronic constipation is a common disease caused by several etiopathogenisis, characterized by dry stool, defecate strenuous and never-failing feeling, obstruction feeling as well as in stool frequency decreases etc. Because of constipation rarely leads to hospitalization and death, so it is harmful to health are often neglected. There are some inter epidemiology reports on chronic constipation in sucession. Age, sex, occupation, education, the psychological barrier, abuse laxatives, bad bowel habit etc are considered to be the risk factors of chronic constipation. Due to chronic constipation seriously affect the quality of life of the patients, as well as increase the incidence of Cerebrovascular accident , also have an important role in colorectal cancer incidence, so early prevention and reasonable therapy will relieve chronic constipation brings the serious consequences. Various areas need to study its incidence, prevalent regularity, etiology by epidemiology principle and methods,in order to formulate rational preventive countermeasures. This is the foundation and the key to reduce the incidence of chronic constipation, and to give reasonable therapy for chronic constipation.Therefore, we have formulated the program to study the detection rate , influencing factors of chronic constipation, and to develop better prevention measures.Methods:Choose the 18 and older healthy crowd who went to the Internal Medicine Clinic as study objet in our Health center during 2009.11.1to2010.1.31,and have a questionnaire survey on them. Investigation contents include:①General questionnaire(Include name, sex, nations, age, occupation, family seat, etc ) ;②Chronic constipation symptoms questionnaire ;③Case-control questionnaire(Include the life dietary habits, cigarettes, hobbies, sleep, bowel habit, intestinal infection history, chronic constipation family history, etc );④Upper gastrointestinal symptoms questionnaire ;⑤Zung depression self rating scale (SDS) and anxiety self rating scale (SAS)。All survey data are inputed into computer and established database, then analyzed by statistical software spss15.0, chi-square test for rate comparison, multi-factor logistic regression analysis is used for the risk factor analysis.Values of P <0.05 were considered to be statistically significant. Result:A toal of 2880 individuals(male 1878,female 1002)are surveyed in our Health center during 2009.11.1-2010.1.31.The average age was 39.32 years old, the male to female ratio is 1.87:1.122 persons were diagnosed as chronic constipation.The detection rate is 4.24%, male 2.29% (43 cases),female 7.88% (79 cases).There was significant difference between male and female(x~2 =50.42,P<0.001)。The detection rate was significant difference between persons of different occupations(x~2= 27.396 ,P<0.001). From high to low as follows: retiree (8.22%), personnel (6.25% ), company staffers (4.82%), cadres (2.78%), businessmen (2.33%), student (2.0%), civil service (1.77%).22 factors including life dietary habits, cigarettes, hobbies, past medical history, family history, sleep, bowel habit etc were analyzed by the method of multi-factor logistic regression analysis.It showed that marriage, nationality, sports, water quantity, fruits and vegetables, whole grains, cigarette, wine, tea, use of antibiotics and nonsteroidal anti-inflammatory drugs had no significant relationship with chronic constipation (P > 0.05); Chronic constipation family history, intestinal infection history, long time in seat, often eat spicy food and sleep difference are chronic constipation risk factors ; timely bowel habit can reduce the risk of constipation.82(67.21%)patients with chronic constipation in 122 have Upper gastrointestinal symptoms , significantly higher than the control group (39,31.97%); Among Upper gastrointestinal symptoms, the rate (59 patients, 48.36%)of postprandial fullness discomfort was the highest, followed by nausea(37cases,30.33%), pharyngeal foreign body sensation(32cases,26.23%), belching(21cases,17.21%), acid regurgitation(19cases,15.57%), retrosternal discomfort (16cases,13.11%), heartburn(11cases,9.02%).The incidence of depression was 32% in Chronic constipation group significantly higher than in control group (10.6%), (x2 = 16.52, P < 0.001); The incidence of anxiety was 36.9% in Chronic constipation group, significantly higher than in control group (13.9% )(x2 = 16.95, P < 0.001).Attitudes towards chronic constipation are different in 122 patients.There were 57(15.6%)patients by diet adjustment, 19 patients (15.6%) voluntarily taking aperient drugs, 21 cases (17.2) had to hospital, 25 cases (20.5%) not any processing.Conclusions: The detection rate of chronic constipation was 4.24% in Health Cheke-crowd, higher in females than males; With increasing age the incidence of chronic constipation was gradually increased. Chronic constipation family history, intestinal infection history, long time in seats, often eat spicy food and sleep sent are risk factors of chronic constipation;timely bowel habit can reduce the risk of constipation. Developing good eating habits and bowel habits in life, adjusting the mental state, is very important in preventing the occurrence of chronic constipation.