Alzheimer's Disease Study Base On Cerebral Cortex Thickness And CSF Biomarker

Alzheimer's disease (AD) is a progressive fatal neurodegenerative diseases, the clinical manifestations of the cognitive and memory function is deteriorating. Through analysis the mild cognitive impairment (MCI) and Alzheimer's brain cortex thickness variation, can understand this disease in the developing mechanism and be of great help for its early clinical diagnosis. This paper mainly through the Mild cognitive and Alzheimer's patients brain magnetic resonance image processing, study analyzed the change of the thickness of the cerebral cortex.First, comparison MCI, AD patients and normal elderly (NC) cortex thickness difference, longitudinal observation MCI and AD patients two years of cortex thickness changes, analysis the patients variation pattern of brain gray thickness. Study found that patients development with brain gray thickness become thinner, first thinned area mainly in default network area which related to cognitive and memory, shrinking area gradually spread, and eventually atrophy led to the whole brain.Secondly, statistical analysis of mild cognitive impairment and Alzheimer's disease in cerebrospinal fluid (CSF) biomarker level, and do the association study of cerebral cortex and the CSF biomarker. We found as the disease development the Aβ1-42 protein content level is reduce, Tau and P-Tau181p protein levels increase gradually. The cerebral cortex thickness has significant correlation with cerebrospinal fluid biomarkers, and the correlation of the most significant areas are mainly concentrated in default network region.Then, study of relation of AD patients hippocampus atrophy with ApoE gene type, we first longitudinal observed the patients of AD hippocampus longitudinal time shrink, found MCI and AD group in 6 months and 12 months after shrinking the size of the hippocampus compare with NC group accelerating, while the hippocampus atrophy of NC no accelerated; In AD patients, ApoE4 genotype carriers of the hippocampus shrinking faster than no ApoE4 carriers faster. The more discusses the ApoE4 type gene is one of the risk factors develop AD.Finally, the relationship between former smoking and AD study, this paper first study of recently literatures which relations of between smoking and AD, using Meta analysis to comprehensive assessment of the relationship between former smoking and AD, found former smoking compare with never smoking develop to AD the relative risk is 0.9 (P=0.03), former smoking has certain protective effect for AD. Then this paper through cognitive abilities, CSF biomarker, and the cerebral cortex thickness study the relations between former smoking and AD, found that former smoking cognitive ability and the cerebral cortex thickness reduce slower than never smoking, Tau and P-Tau181p protein content was significantly lower than never smoking population. Former smoking can relay MCI and AD develop.