Clinical Research Of Liujunzi Decoction On Treating The Patients With Chronic Atrophic Gastritis

Objective:To observe the clinical curativate effect to treat of chronic atrophic gastritis (type of defieiency of the Spleen and stagnancy of Liver Qi) by Zhichai Liujunzi Jiawei and to explore possible mechanism and to provide effective preseriptions for the clinical treatment of atrophic gastritis.Methods:According to diagnosis standards, inclusion standards and climination standards,60 cases with Chronic Atrophic Gastritis are selected. They are separated into two groups with random and comparison method, treatment group and control group, which each group has 30 cases, the two groups in gender, age, main symptoms, signs, endoseopy and pathology has no significant differences(P>0.05). Of which 30 are in the treatment group with the administration of Zhichai Liujunzi Jiawei Deeoetion, a day one dose which is Divided into two times,30 are in the control group with the administration of Weifuchun, a day twelve chips which is divided into three times, two groups are two months of a course of treatment. After the end of a course of treatment, we observed the effect of symptoms, signs, endoscopy and pathology both two groups before and after the treatment.Results:1. The treatment group:3 cases were clinically cured,10 markedly improved,9 effective,8 ineffective, the total effective rate was 73.33%; the control group:2 cases were clinically cured,9 markedly improved,8effective, 11 ineffective, the overall effective rate was 63.33%. There was not significant difference between two groups(P>0.05). All participants in the trial have not suffer adverse reactions.2. In improving endoscopic mucosal in treatment group is significantly better than the control group (P<0.05).3. The treatment group in the stomach pain, vomiting of water, eating, is better than the colltrol group(P<0.05), no significant difference efficacy between the two in the distention, loose stools, shortness of speaking, ete(P<0.05).4. The improvement of histopathologic integral was better than the control group(P<0.05).Conclusion:The correlation analysis shows that not only Zhichai Liujun Jiawei Decoction in treatment of CAG of type of deficiency of the defieiency of the Spleen and stagnancy of Liver Qi, but also significantly reverse chronic atrophic gastritis of the pathological state, which further reveals that the Zhichai Liujun Jiawei Decoction treats chronic atrophic gastritis is reasonable, and prompt the mechanism which may be relate to resisting pathogens micro-organisms, regulating immunity, eliminating of inflammatory and pain, improving gastric mucosal microcirculation, enhancing gastric mucosal barrier removing oxygen free radieals, resisting tumor, promoting gastroiniestinal motility, and anti-bile reflux.