| ObjectiveWe treated the depression patients (patients were divided into treatment groups:manipulative therapy group and control group:normal acupuncture group)with acupuncture treatment in this project, following the principle of evidence-based medicine, clinical epidemiology/DME. The results were processed and analyzed with statistical methods and the efficacy and safety of manual therapy was evaluated in order to provide a new way for the treatment of depression.Methods70 patients with depression treated in Guangzhou the First Affiliated Hospital of Traditional Chinese Medicine clinic and the martyrs of the East and Huangpu Town Zhongshan City People's Hospital during March 2010 to March 2011 were enrolled according to the screening criteria in this project.All the patients were divided into Experimental group and control group By 1:1 ratio randomly,35 cases of each group. Experimental group received manual therapy and control group received normal acupuncture therapy. The treatment was 3 times a week,6 times for a course, we observed 2 courses. We got the results by the HAMD scale score, self-rating depressiveseale (SDS) scale, Syndrome Scale scores and sleep scale score points before treatment and after a course of treatment and make safety testing. We evaluated clinical efficacy by the reducing rate of total HAMD score. Scores decreased as the condition improved. Final score<8 or reducing rate>75% for the clinical cure, reducing rate>50% as markedly,>25% for the better,<25% as invalid.We established database by EPIDATA3.1 and analyzed them with SPSS15.0 statistical software. Continuous variables were expressed as mean±SD, while categorical variables were expressed as ratio or percentage. The comparison of continuous variables between groups was analyzed by t test (variance arrhythmia using t'test or rank sum test), the comparison of variables before and after therapy was analyzed by paired t test or Wilcoxon paired rank test. Classified information between the two groups was analyzed by X2 test, the difference between groups of categorical variables were analyzed by Wilcoxon rank test.ResultThis study collected 70 cases of qualified outpatients.65 cases were actually completed, including 29 males and 36 females, aged 21-65 years old, duration of two weeks-23 months. Treatment group was 33 patients (14 males and 19 females) and control group was 32 patients (15 males and 17 females), mean age of both groups were 45.37 years and 42.75 years, mean duration was 5.82 months and 5.75 months. There were no statistically significant in the comparability of baseline characteristics of patients in the two groups in gender, age, disease duration, severity, HAMD points before treatment, self-rating depressiveseale (SDS) scale, Syndrome Scale scores and sleep areas by analysis of scale score points, indicating that the baseline data between two groups were comparable.The comparison of clinical effects in two groups after 2 courses of treatment:the experimental group was 33 patients, while 9 cases were clinical cure,14 cases were markedly effective,8 cases were better,2 cases were invalid, the total effective rate was 93.94%; the control group was 32 patients, while 7 cases were clinically cured,14 cases were effective,2 cases were better,2 cases were invalid, total effective rate was 93.75%. The comparison of difference between two groups in clinical efficiency was statistically significant (P<0.05). But there was no difference in comparison of total effective rate in 2 groups (P> 0.05).The two treatment methods are effective in reducing the HAMD scale score (P<0.05), but the effects were different, the treatment group was more evident than control group in decreasing HAMD scale scores (P<0.05).After 1 course of treatment, the comparison of treatment group and control groups before and after SDS scores showed that both had statistically significant (P<0.05), indicated that two treatment methods were effective;there was no difference between 2 treatment methods in reducing depression factor score (P> 0.05). However, after two courses of treatment, the difference between 2 groups was statistically significant (P<0.05), showed that the treatment group was superior than control group.Two treatment methods were effective after 1 course of therapy in TCM syndrome Scale scores (P<0.05), and similar in efficacy (P> 0.05); at the end of treatment, the results between 2 groups in improving TCM syndrome Scale scores showed that treatment group was better than control group (P<0.05).After 1 course of treatment, the difference before and after therapy in each group and between 2 groups in sleep scale scores points were both statistically significant(P<0.05), indicated that the two treatments were effective in improving scale score points, but the treatment group was better. Observed adverse events:no adverse reaction after treatment.ConclusionThe technique of acupuncture treatment is effective to reduce scale score in patients by HAMD Scale scores, SDS score, TCM Syndrome Scale scores and sleep scale score points, also has an overall improvement in improving depressive symptoms and is more effective than control group in reducing the amount score of HAMD Scale scores, improving sleep syndromes and the condition of sleep. Markedly effective rate of clinical efficacy between treatment group and control group is no difference. All the results of clinical studies initially proved that treatment of acupuncture in depression patients can significantly improved clinical symptoms, and is effective, safe and reliable, can be generalized in clinical work. |
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