Applied Research On Normal Cervix And Cervix Cancer By T1 Perfusion Weighted Imaging

Objective:Using Magnetic resonance imaging (MRI) perfusion weighted technology (DWI), To explore the characteristics of time-signal intensity curve (TIC) and the differences in perfusion parameter of uterine cervix cancer and normal uterine cervix. Discuss the normal cervical and cervical cancer PWI performance characteristics and clinical application value.Materials and Methods:Using 1.5T MRI, do MRI scan and PWI for the postmenopausal uterus group (21 cases)and not postmenopausal uterus group (26cases),and the cases of Uterine Cervix Cancer (27cases). Observe each group perfusion imaging time-signal curve (TIC), and analyze the characteristics of curve. Use of TIC curve, further obtains each areas of interest perfusion imaging parameters:Sleepest slope (SSmax),Maximum enhancement ratio (MER),peak height (PH), Time-to-Peak(TTP).And do related statistical analysis about the Perfusion imaging parameters for each group. MRI scanning use T1WI-TSE, T2WI-TSE, T2WI-STIR and Gd-DTPA enhanced T1WI-TSE—FS sequences in the transverse, sagittal, coronal planes scanning and transverse T1WI perfusion Imaging scanning.Result:(1) Rapid rise with gradual decline TIC predominated in the 27 cases with Uterine Cervix Cancer, exhibiting a notable upslope and a plateau after Peaking. Among the 27cases,22 cases showed rapid rise with gradual decline; 25cases showed rises lowly. In the 47 control cases,31 cases showed rise slow type,9 cases showed rapid rise with gradual decline,7 cases showed the type between the "rapid rise with gradual reduction" and "slow up". (2) Among MR perfusion parameters, the mean value of SSmax,MER,PH and TTP was not statistically significant between the group of the normal postmenopausal and not postmenopausal(P=0.051,0.064,0.184 and 0.862,respectively); the mean value of SSmax,MER,PH and TTP was not statistically significant between the group of the Cervical squamous cell carcinoma and cervical adenocarcinoma(P=0.892,0.881,0.880 and 0.956,respectively); There was significant difference in SSmax,MER,PH and TTP of the TIC between uterine cervix cancer group and uterine cervix cancer group. The TTP value of Uterine cervix cancer group was significantly shorter than uterine cervix cancer group.Conclusion:MRI can reflect the pathologic features of the Uterine Cervix Cancer tissue and the control, which could be used to distinguish Uterine Cervix Cancer tissue and the normal tissue. The TIC and Perfusion parameters can reflect the changes of signal and enhancing rate therefore the characteristics of blood supply in Uterine Cervix Cancer tissue were also reflected, which could help with the etiologic diagnosis of Uterine Cervix Cancer. PWI of uterine histopathological changes can be determined, the conventional MRI morphology and the pathological changes of the information provided PWI combination, what can compensate for the limitations of conventional MRI of endometrial carcinoma, improve the early diagnosis and diagnosis accuracy has certain clinical significance.