Meta-analysis On The Association Of Autoantibodies Ocurrence With Clinial Characteristics And Efficacy Of IFN In CHC Patients

Objective:Since there is still inconlusive that the previous studies about autoantibodies in chronic hepatitis C (CHC) patients with clinical features and their antiviral efficacy of treatment, this paper systematic review of previous research to understand the clinical features and efficacy of antiviral treatment.MethodA search in the Pubmed, Embase, CNKI, Wangfang and Vip databases from January 1989 to December 2010 was made. Two reviewers independent assessed the quality of the publication and collected the data of basic information.Meta-analysis are processed using RevMan software(version5.0.21) with odds ratio(OR) and weighted mean differences as statistics. Selected fixed or random model based on the heterogeneity test. Sensitivity analysis is done by transform models, excluding the maximun and the minimus weght of the studies. The publication bias is evaluated by funnel plots.Results:10 trails involving 1810 CHC patients were included by Meta-analysis.436 of them were positive for autoantibodiy and 1374 were negative.It showed difference statistically between positived autoantibody and ages in CHC patients, p=0.02, WMD 3.38,95%CI [0.50-6.26]. The rate of positive antibody raise with growing of age.It was showed that there was stasticaly difference between the positive autoantibody and the gender in CHC patients. In male, it conclude p=0.02, OR 0.77,95%CI[0.50-6.26]. In female, the conclusion was p=0.005, OR 1.37,95%CI[1.10-1.72]. So, the positive autoantibody is lower in male and higher in female.There was no statistical difference between positived autoantibody and gene type of HCV in CHC patients. In gene type-1, it concluded that p=0.73, OR 0.96,95%CI[0.73-1.24]. In other gene type, the conclusion was p=0.54, OR 0.92,95%CI[0.69-1.21]. There was no association between autoantibody and the gene type of HCV. It was showed that there was stasticaly difference between the positive autoantibody and AST level(p=0.010, WMD 19.32, 95%CI[4.69-33.94]) and ALT level(p=0.0001, WMD 47.06,95%CI[22.75-71.36]). In CHC patients with positive autoantibody, the AST and ALT level is higher than with negative. Mata-analysis also concluded there was no statistical difference between positived autoantibody and the efficacy of IFN antiviral treatment in CHC patients, p=0.095, OR 0.97, 95%CI[0.43-2.21].Conclusion:The autoantibody was association with some clinical characteristics in CHC patients,such as age, gender, gene type of HCV, AST,ALT. The probability of positive antibody increased with increasing age.It was lower in male and higher in female. There was no association between autoantibody and the gene type of HCV. In CHC patients with positive autoantibody, the AST and ALT level is higher than the negative one.There is no association between the autoantibody and the efficacy of antiviral therapy for CHC patients.