Application Of Preemptive Analgesia In Breast Implants Surgery

Objective:Through the application of dezocine and ketorolac tromethamine,this study investigates and compares the feasibility,safety and clinical application effect of their preemptive analgesia for the postoperative analgesia of breast augmentation surgery.Methods:the research methods are as follows:（1）Selection and grouping of cases:With the approval of the hospital ethics committee,60 cases were elected.The breast augmentation Book Women,who agreed and signed informed consent,aged from 20 to 60 years old with the height of 151¹76cm and weight of 45⁶5kg.These people are without chronic severe pain of history,no alcohol and drug abuse history,preoperative combined with severe liver and kidney disease,with respiratory dysfunction,no long-term use of analgesics,American Society of anesthesiologists（American Society of Anesthesiologists,ASA）Ⅰ-Ⅱ.（2）Anesthesia methods:The patients were randomly divided into three groups and each group had a total of 20 cases,all of which were female.Group N was the control group,which is based on the conventional intubation without full preemptive analgesia（Intravenous saline before operation）.Group D（Intravenous Dezocine before operation）;Group T（Intravenous ketorolac tromethamine before operation）.Three groups of patients were treated with intravenous patient-controlled analgesia（PCIA）.Preparation method:sufentanil 2μg/kg,granisetron 6mg with an addition of 0.9%ns to 100ml,continuous infusion rate of 2ml/h+P in a dose of 2ml/,dosage of 0.5ml,lock time 15mins)48 hours after the use of PCIA in surgery.（3）Intraoperative observation:Observation of non-invasive systolic blood pressure（SBP）,noninvasive diastolic blood pressure（DBP）,heart rate（HR）,pulse oxygen saturation（SpO₂）changes,and visual analogue scale（VAS）assessment for postoperative breast augmentation postoperative 4 h,8 h,12 h,24 h,36 h,48h the feeling of pain,analgesia pump effective trigger number and postoperative drowsiness,nausea and vomiting,skin itching and other related adverse reactions.Results:the results are as follows:（1）There was no significant difference in age,weight,height,ASA classification and operation time between the three groups（P>0.05）.（2）Compared with postoperative 4-48h analgesia VAS score,the VAS score of patients in group T and group D were decreased（P<0.05）,and the number of effective trigger times after operation was significantly reduced（P<0.05）;group T and D were not statistically significant.（3）Comparing the three groups of patients with 8h,12h,4h,24h,36 h and 48h at different time points of life sign,hemodynamics of Group T compared with group N and group D was more stable.The SBP,DBP,HR in group T and group D significantly reduced compared with group N（P<0.01）,there was no respiratory inhibition phenomenon in all three groups after operation and SpO₂ waved in 97%¹00%.（4）To observe the adverse reactions of three groups of postoperative nausea and vomiting,chills,three groups of breast augmentation postoperative nausea and vomiting,the incidence of respiratory depression and the difference was not statistically significant.Conclusions:（1）In the clinical dose range,small dose of dezocine and ketorolac tromethamine has the preemptive analgesic effect compared with general anesthesia alone.Using dezocine and ketorolac tromethamine combined with general anesthesia of preemptive analgesia can improve postoperative analgesia,reduce postoperative pain degree,and does not increase postoperative adverse reactions.（2）Dezocine and ketorolac tromethamine showed no significant difference in the preemptive analgesia effect which is basically equivalent.