| Jumi, the flower buds of Chrsanthe memindieum (Chrysanthemum indium L.), has been recorded in " Supplement to Compendium of Materia Medica" by pharmaceutist Zhao Xue-min in Qin Dynasty and used for a long time as Chinese traditional medicine in antibacterial, anti-inflammatory activities and to facilitate discharge of urine,protect liver, improve eyesight, decrease blood pressure and keep weight. In the present study, the extraction and purification of flavonoids from Jumi has been investigated. By the combination of ultrasonic and cellulase techniques we raised a novel and optimum method to isolate and purify successfully the flavonoids from Jumi by using of the chromatography with macroporous resin according to the single and orthogonal test; The Jumi extracts were used as raw material for extracting flavonoids prepared pellets, results showed that content of the bio-active compounds, water content and other physical characters had no obvious deterioration in 10 months; The HPLC fingerprint was established for quality assessment and control of Jumi extract and capsules; By using SHR and hyperlipidemic model rats, level of decreasing blood pressure (BP), heart rate (HR) and antiatheroscloresis ability of food-roune hyperlipidemia in rats by total flavonnoids from Jumi were observed in this study. Jumi is an important agricultural product in Zhejiang Province, therefore, the extraction and purification of its functional components and the development of health food products with high added value are of great significance for the development of economy and society.
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