The Relationship Between Response Of High Blood Glucose And Inflammatory Cytokine, Prognosis In Patients With Critical Diseases

Objection:To investigate the relationship between response of high blood glucose and inflammatory cytokines, prognosis in patients with critical diseases.Method:A total of 65 patients with critical diseases were inrolled in the study. The concentration of blood glucose, tumor necrosis factor-a(TNF-a) and interleukin-6 (IL-6) of the samples were measured in 24 hours after hospitalization. The patients were randomly divided into two groups:the insulin treatment group and the conventional treatment group.The clinical effect was observed on the 30th day after the treatment.Result:The concentration of blood glucose, TNF-a and IL-6 of the samples of test group increased obviously, which had significantly difference from the control group(P< 0.01,P<0.001).And the change of these factors was significantly related to the result of APACHEâ…¡and final prognosis (P<0.01). The concentration of blood glucose was significantly positive correlation to TNF-a and IL-6 (r=0.6256, r=0.5674). No significant difference was found between the prognosis of insulin treatment group and the conventional treatment group (P>0.05).Conclusion:The classical treatment for patients with critical diseases need to be adopted urgently.Resisting the serum inflammatory cytokine including TNF-a, IL-6 and so on and increasing insulin sensitivity might be another key of measurement to treat response of high blood glucose in patients with critical diseases.