Systematic Reviews Of The Treatment Of The Compound Traditional Chinese Medicine On Immune Infertilitas Feminis With Positive Antisperm Antibodies

Objective: Analyse systematically the effectiveness and security of the compound traditional Chinese medicine on immune infertilitas feminis with positive anti-sperm antibodies, in order to make objective and credible eva- luation,instruct clinical treatment.And we can propose the problems in clini- cal studies and measures to be taken.The result provided the best evidence currently available for the patients who choose to use compound Chinese herbal to treat disease and the basis and foundation for the future clinical studies.Through such methods, the expand and applications of the treatment of the compound traditional Chinese medicine on immune infertilitas feminis with positive anti-sperm antibodies can be promoted.Methods: By using the evidence-based medicine approach, compre- hensively search the randomized controlled trials of the clinical experiments published in domestic and foreign of treatment of compound Chinese herbal on the anti-sperm antibodies of immune infertility , and evaluate the quality of the research literature in accordance with the modified Jadad quality score method . By RevMan4.2 (Review Manager) free software and choosing a fixed or random effects models according to the heterogeneity test , calculate odds ratio (OR) and 95% confidence interval (CI).For the comparison of theclinical total effective ,cure rate and relapse rate, we can use Chi-square test for the statistical analysis.Results: A total of 12 studies met the inclusion criteria.a group ofChinese herbal formula treatment totally includes 660 patients,589 cases of which have effective treatment and 331 cases cured; Western control group patients have a total of 426 cases, of which only western group of 237 cases,simple tools (condoms) group of 154,and only western + tool (condoms) group of 35, and the effective number is 237, the cured 71. Studies have shown that in the aspect of the clinical total efficiency and overall cure rate after the end of the treatment on the compound traditional Chinese medicine on immune infer- tilitas feminis with positive anti-sperm antibodies, Chinese herbal formula treatment group is higher than Western medicine control group, while for the clinical total recurrence rate, traditional Chinese medicine compound is lower than Western medicine control group.The odds ratio are: OR = 8.34 (I2 = 14%, fixed effects model, 95% CI :5.86-11 .87 P <0.01), OR = 5.33 (I2 = 0%, fixed effect model, 95% CI :3.87-7 .35 P <0.01), OR = 0.09 (I2 = 0%, fixed effects model, 95% CI :0.04-0 .21 P <0.01).Conclusion: The clinical total effective rate of Chinese herbal formula treatment of immune infertility with positive antisperm antibody is 8.34 times of the Western control group, and clinical total cure rate 5.33 times , while the clinical relapse rate of Western medicine control group is 0.09 times of Chinese herbal formula treatment group. Because of the low quality of the inclusion of randomized controlled trials , there are potential publication bias, and the clinical efficacy and safety need to be further confirmed in the future by a large randomized controlled trials .