| Objective To observe the relationship between blood N-terminal fragment of brain natriuretic peptide prohormone (NT-proBNP ) to different infarct site and the effection of bisoprolol on NT-proBNP in patients with acute myocardial infarction (AMI).Methods 98 patients with acute myocardial infarction were divided to the posterior wall infarction group (A group, n = 22), anterior and lateral infarction group (B group, n = 24), pre-septal infarction group (C group, n = 20) and extensive anterior infarction group (D group, n=24) according to the characteristics of electrocardiogram; 23 age-matched patients with non-coronary heart disease as a control group. Plasma NT-proBNP of all patients were measured within 24h after admission by ELISA methods. The patients with AMI were randomly divided into conventional treatments group (n= 48) and bisoprolol treatments group (conventional treatment plus bisoprolol, n = 50). The plasma NT-proBNP were measured after 1 week and 1 month treatment respectively.Results The plasma NT-proBNP levels in patients with AMI were D group> B group> C group> A group >control group (P <0.05), and there were significantly decreased after 1 week and 1 month treatment (P <0.05),there were statistically significant differences between between the two groups (P <0.05) and significantly decreased in bisoprolol group (P <0.05).Conclusion The plasma NT-proBNP showed significantly increase and relationship to the infarct site in patients with AMI, and .the patients with extensive anterior wall myocardial infarction showed the most obvious in the level of plasma NT-proBNP; Early using bisoprolol can significantly reduce the plasma NT-proBNP level in patients with AMI.
|
PDF Full Text Request