Low Molecular Weight Heparin Improve Microcirculation On The Rats Of Severe Acute Pancreatitis

ObjectiveTo study the effects of low molecular weight heparin (LMWH) on pancreatic microcirculation on the rats of severe acute pancreatitis.MethodsWistar rats were randomly divided into 3 groups:(1)Sham operation(S)group;(2)SAP group(;3)LMWH treatmen(tL)group. Compare the three groups concentrations of serum tuˉmor necrosis factorα(TNF-α),Bradykinin(BK) and Pancreatic pathological section .ResultsCompared with S group , TNF-α, BK in SAP group were significantly increased(P<0.05,<0.05)and Increase the degree of pancreatic tissue sections lesion;After LMWH treatment,TNF-α,BK decreased significantly compared with SAP group(P<0.05,<0.05)and degree of histological lesions in the pancreas significantly improved.ConclusionThe results suggest that LMWH can Improve the rate of SAP microcirculation pancreas by down-regulate the levels of serum TNF-αand BK,thus reduce pancreatic necrosis.