The 1:1 Matched Case-control Analysis On The Relative Factors Of Amblyopia

Objective To investigate the major relative factors of amblyopia in children.Methods A 1:1 matched case control study was used in 100 paired cases and 100 controls. The major factors impacted on the occurrence of amblyopia, including the congenital factors, acquired factors and the nutritional factors, were analyzed by condition logistic regression model.Results Single factor analysis showed that the risk factors of amblyopia included times of pregnancy, daylight of child's habitual room, child-bearing age of father, content of calcium, copper and Zinc in hair of child and glutathione pexoxidase in blood; sugar, fruit, vegetable, bean and seafood-intake, the duration of computer and fruit, bean and seafood-intake during pregnancy. A furthermulti-regression analysis confirmed that six factors, including times of pregnancy, daylight of child's habitual room, sugar-intake, hair Zinc content and glutathione pexoxidase in blood of child, were mutually related to the occurrence of amblyopia, seafood was protection factor. There are interaction action among times of pregnancy, daylight of child's habitual room and sugar-intake. sugar-intake and amblyopia has dose-response relationship.Conclusion More times of pregnancy, poor day-light of child's habitual room, sugar-intake,low content of Zinc in hair and glutathione pexoxidase in blood of child can increase the risk of amblyopia, seafood was protection factor. Times of pregnancy and sugar-intake had antagonism action in interaction,dallight of child's habitual room and sugar-intake had synergistic action in interaction supported by additive model. Sugar-intake and amblyopia has dose-response relationship.