| MKP-1 and Nrf2 are closely related to the drug resistance in Non-small cell lung cancer, while MKP-1 and Nrf2 have been shown to be associated with cellular stress, tumorigenesis, MAPK, JNK, GSK3βand PI3K, which implies that MKP-1 maybe related to Nrf2. The role of MKP-1 may be important for the Keapl-independent degradation of Nrf2 in non-small cell lung cancer cells. This study shows that MKP-1 or JNK can directly interact with Nrf2 and JNK plays an important role in the regulation of Nrf2 by MKP-1 in non-small cell lung cancer cells. The hypothesis is significant for the research on the regulatory mechanism of Nrf2 in non-small cell. In addition, we also study on the biological function of Nrf2 in resistant cell lines (high expression of Nrf2) and sensitive cell lines (low expression of Nrf2). Results show that reducing the expression of MKP-1 by siRNA can sensitize anticancer drugs more significantly in the resistant cell lines compared to the sensitive cell lines, which means Nrf2 plays an important role in the MKP-1-dependent drug resistance.
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