| ObjectiveThe purpose of study is to explore the expression of Stathmin in gastric cancer and adjacent tissues. With analysis of the relationships of Stathmin and clinical pathologic characteristic of gastric cancer, to provide the reference for the clinical individuation medication and the prognosis judgment.Materials and MethodsThe expression of Stathmin were detected in 34 stomach carcinomatous tissues and 34 adjacent tissues by using immunohistochemistry SP method and RT-PCR technique. All of the tissues were collected from surgical procedures in our hospital from January to June 2008, which were confirmed by pathology and the data was intact. Expression of both gastric cancer and the clinicopatho-logical characteristics and the relationship between the two expres- sion in gastric cancer correlation statistical analysis.ResultsThe expression of Stathmin increased significantly(P<0.05) in gastric cancer tissues compared to the adjacent tissues; the over-expression of Stathmin in gastric cancer was positively related to the differentiated degrees of the tissues (p<0.05), which means more Stathmin were detected in poorly intermediately differentiated adenocarcinoma than in those highlydifferentiated ones; the over-expression of Stathmin in gastric cancer was obviously related to the depth of invasion, lymphatic metastasis and clinical stages (p<0.05). It indicated that the Stathmin level is higher in the penetrated serosa(p<0.05), lymphatic metastasis(p<0.05) and Phaseâ…¢-â…£(P<0.05) than in that without invasion, without lymphatic metastasis and Phaseâ… -â…¡, respectively. However, it did not relate to the patient's age, sex (p>0.05). This implies the upregulating levels of Stathmin is significantly correlated with some malignant behaviours of gastric cancer. ConclusionThe level of Stathmins expression in carcinomatous tissues is higher than the level in the adjacent tissues. Stathmin protein and mRNA expression associates with the degrees of differentiation which means the levels of Stathmin protein and mRNA expression is higher in the advanced-differentiation adenocarcinoma than in the poorly differentiated one. Stathmin protein and mRNA expression are positively correlated to clinical stages, the depth of invasion and lymphatic metastasis, meanwhile, it has nothing to do with the patient's age, sex... |
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