Synthesis Of Chrysin Piperazine Phosphate Derivates And Their Interaction With Bovine Serum Albumin

Malignant tumor is a serious disease which threatens to human health and life. In order to find new efficient, low toxicity, high bioavailability target molecules, the structure modification of lead compounds from some natural active ingredients, is an important way to find anti-cancer drugs in recent years. Chrysin, (5, 7-dihydroxyflavone), which is widely distributed in plants has been known to have many biological activities including antioxidant, antibacterial, anticancery, anti-inflammatory, antiallergic, antiesrtogenic, and anxiolytic antivities, but little or no absorption in the intestine results their lower activity. To obtain high efficiency, low toxicity of new lead compounds, appropriate modification of chrysin and mechanisms in therapy have become an important research field attracted by scientists at home and abroad.The main research work of this thesis is as follows:1. The recent studies on pharmacological action, extraction and isolation, pharmaceutics and structural modifications of chrysin were reviewed.2. According to the principles of drug designing, mopholine, piperazine and nitrogen mustard which have certain biological activities were induced into chrysin, some novel series phosphate derivatives of chrysin were synthesized. The structures of all the newly synthesized chrysin analogues were elucidated by ESI-MS, NMR and IR.3. The non-covalent interactions are studied between bovine serum albumin and different chrysin phosphates by means of fluorescence spectrum.