| Objective:To investigate the protective effect of PEG1 and Adenosine perfusion on the isolated lung.Methods:18 rabbits were randomly divided into 3 groups which contain control group(A), UW fluid with PGE1 group(B), UW fluid with adenosine group(C). Dissociate the lung and heart of rabbit as the isolated lung and heart model. Perfuse the model with low temperature perfusion fluid and conserve the model in the same temperature perfusion fluid. The lung specimens were obtained in order to analyze the change in morphology by using electron microscope at 2 and 4 hours after perfusion. Detect the ratio of wet/dry weight (W/D); airway pressure(Paw) of lung model; gas analysis of the blood which was pumped into the lung model through main pulmonary artery and then the blood which was elicited from left atrium pulmonale by using a vacuum aspiration tube after 4 hours of perfusion.Results:The protective effects on the function of the lung tissue gas exchange and the moisture capacity of group B were better than those of group A and C significantly. The protective effect of group C on Paw, moisture capacity and the function of lung tissue gas exchange was better than that of group A. Conclusion:Perfusion of the isolated lung with PGE1 can get longer time of preservation and better preservation of the function of lung tissue gas exchange than that with UW solution.
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