| Diabetes is the third in the diseases which induces died. Nowadays there are 9,200,000 diabetes in China, China is the NO.1 diabetes in the world. What's more, fat and sitting and lying style habits becomes more and more popular, The incidence of diabetes will continue to rise. Type 2 diabetic nephropathy is one of the most complications, whereas, there isn't effective drugs.In this paper, establish a reasonable model of type 2 diabetic nephropathy methods rats, Which are two different type 2 diabetic nephropathy in the modeling method, model 8 weeks to compare the blood glucose levels, insulin resistance and renal function. The results showed that the blood glucose and microalbuminuria in the group of high glucose and high fat diet for 4 weeks after the intraperitoneal injection of low dose streptozotocin is 27.95 mmol·l-1 and 129.73μg·l-1. That this method can establish a stable type 2 diabetic nephropathy rat model, and simple, less human impact.In addition, through the use of Apocynum extract on rat model of type 2 diabetes after the intervention, rats model of high blood sugar levels and no significant difference, but the treatment of renal dysfunction in a dose-dependent recovery. The results showed 76.2% reduction of urinary albumin, indicating that Apocynum extracts play a significant protection of renal function.Then serum levels of glycosylation, oxidative stress, tumor necrosis factor-a, transforming growth factor-βcytokine researched. Experimental results showed that glycosylation, tumor necrosis factor-a, transforming growth factor-βdecreased by 48.2%,63.1% and 51.2%, and significantly lower levels of oxidative stress. Tips Apocynum extract by reducing glycation and oxidative stress protection of renal function impairment. |
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