Epidemiology Study Of Carotid Artery Intima-media Thickness And Plaque In Hypertensive Adults Of Lianyungang Rural Community

Objectives: This study aims to describe current situation of carotid artery intima-media thickness (CIMT) of the hypertensive adults of Lianyungang community, and association of CIMT with blood pressure (BP), fasting blood glucose (FBG), total cholesterol (TC) and smoke. Methods: Subjects aged 45-75 years old of the study were recruited by random sampling from Lianyungang communities during 2008/10 to 2009/6, used clinical epidemiology survey method to investigate information. BP was measured by standard operating procedures, TC was detected by automatic biochemical instrument. CIMT and plaque were measured by specializing trained person using a color ultrasound equipment. Data analyzed by statistician using univariate and multivariate analysis. Results: The object of this study included 1346 people, including 585 men, 761 women. The average age was 59.88±7.65 years in men and 58.59±7.32 years in female. The average thickness of CIMT was 0.72±0.14mm in male and 0.70±0.14mm in female. The detection rates of plaque were 49.1% of men and 32.5% of female. Average systolic blood pressures were 167.91±20.84mmHg in male, and 169.69±20.99mmHg in female. TC was 5.26±1.15mmol/L of men and 5.47mmol/L of women. 30.8% of men never smoked, 51.7% of men were current smoking. 94.6% of women never smoked, 2.9% of women were current smoking. Systolic blood pressure was positively correlated with CIMT. The detection risk of plaque increased with the classification of hypertension increased, but because of the lack of the healthy people with normal blood pressure as control, the result has no statistical significance. FBG has nonlinear relationship between CIMT. However, patients with FBG≥7.0mmol/L has increased risk to detect more than 2 plaques. TC in the male subjects showed a positive correlation with CIMT, patients with TC≥5.69mmol/L has increased risk to detect CIMT> 0.8mm. TC of women has no clear linear relationship with CIMT. However, patients with TC≥5.69mmol/L has increased risk to detect plaque. CIMT was positively associated with smoking. CIMT of objects gradually increased in never, ever and current smoking group. Current smoking objects have increased risk to detect plaque. Conclusions: Atherosclerosis has a high prevalence in hypertensive adults in this community. CIMT thickness positively correlated with systolic blood pressure. FBG≥7.0mmol/L in hypertensive patients with increased carotid atherosclerosis risk. TC≥5.69mmol/L in hypertensive patients with increased carotid atherosclerosis risk. Current smoking male of hypertensive patients has increased atherosclerosis risk.