Therapeutic Efficacy Analysis Of Medicines In The Early Period Of Acute Upper Respiratory Tract Infection Caused By Virus Infection

Objective:To observe therapeutic efficacy of several medicines in the earlier period of acute upper respiratory tract infection through clinic case control study, we want to explore the clinic value of antivirus and antibiotic treatment on acute upper respiratory tract infection, to guide clinical medication of acute upper respiratory tract infection.Method:Selected 386 patients as research objects, they were out-patients visiting the general hospital of Jincheng coal corporation from the August of 2008 to the August of 2009.All of them diagnosed in the early period of acute upper respiratory tract infection caused by virus infection. And they were randomly devided into three groups, then seperately devided into two types:mild type and severe type.A group were given by general treatments(rest, relieve fever);B group were given antiviral therapy(ribavirin or acyclovir);C group were given antiviral therapy combined with antibiotic treatment(choose one of penicillin,levofloxacin,amoxicillin,roxithromycin,lijunsha).Compared with body temperature declined rate and clinic symptoms relieve rate among three groups afer three days'treatment, we want to explore the application of antiviral therapy and antibiotic treatment in the early period of acute upper respiratory tract infection caused by virus infection.Results:1. Of 386 patients with acute upper respiratory tracts infect caused by virus,219 patients were Male and 167 examples were female.193 patients were below 40 years old,193 examples were above 41 years old.202 patients'body temperature is above 38.5℃; 184 patients'body temperature is below 38.4℃; 270 patients felt headache,216 patients coughed expectorate,281 patients felt running nose,150 patients felt swallows uncomfortable,206 patients felt tunica conjunctiva oculi hyperemia.2. Three groups of patients in mild type had no significance in body temperature height distribution. Three groups had no significance in temperature declined efficiency after three days'treatment (P>0.05). But in severe type patients, A group had significance differences compared with B group and C group (P<0.05). Compared with B group, C group had no significance difference(P>0.05). B group and C group in temperature declined efficiency were higher than A group.3. Three groups of patients'clinical symptom distribution in mild type had no significance difference (P>0.05).but patients in severe type, A group had significance difference comparing with B group and C group (P<0.05). Compared with B group, C group had no significance differences (P>0.05). B group and C group were higher than A group in clinic relieved rate.4. Standardized cure rate of A group was 36.27%;that of B group was 53.63%. that of C group was 52.20%. Standardized cure rate of B group is the highest, The next is C group. Standardized cure rate of A group is the lowest.5. After three days, in-cure patients have given the further treatment. Comparing the healing time of three groups, there has significant difference between A group and B group,A group and C group(P<0.05). There is no significant difference between B group and C group (P>0.05). Comparing A group, the healing time of B group and C group is obviously reduced.Conclusions:1. Acute upper respiratory tract infection is primarily antiviral infection in early period. The mild patients may self-recovery through the rest and the objective to symptom treatment for the illness.2. Servere patients not only need have a rest, the general treatment combined with anti-viral treatment.3. In early period of acute upper respiratory tract infection,patients do not need to use the antibiotic treatment, because the antibiotic treatment not only increase expense of the hospitalized patients but also don not reduce time of in hospital.