Research On The Relationship Between Serum Adiponectin And Vascular Remodeling In Essential Hypertension Patients

Obesity:To evaluate the relationship between the adiponectin (APN) levels and intima-media thickness (IMT),ankle brachia index (ABI) in patients with essential hypertension(EP).Methods:120 patients with essential hypertension and 40 healthy subjects were studied.Then we divided the EP group to 3 subgroups according to the blood pressure levels.Serum adiponectin was assayed by radio-immunoassay (RIA), and related parameters such as blood pressure,height,weight,waist circumference (WC) and so on were measured. According to the typical HOMA model, insulin resistance index (HOMA-IR) were calculated.Intima-media thickness and ankle brachia index were both determined.Results:(1)Compared with the healthy group, the serum APN,ABIof the EP group was lower and the IMT was higher (P<0.05). The differences of serum APN,IMT between healthy group,1,2,3 subgroups were both significant. (2) Pearson-correlation analysis revealed APN of EP group was negatively correlated with SBP,DBP,BMI,TG,HOMA-IR,IMT(P<0.05, P (0.01). APN was positive correlation with ABI(P <0.05). (3) Multiple regression analysis showed that age,SBP,BMI,TG were independent factor to logAPN in EP group (R2=0.580, P<0.05).Conclusion:The serum adiponectin has a closed relationship with intima-media thickness and ankle brachia index. Adiponectin maybe joined in the process of hypertension. It suggests that APN could be the index to vascular remodeling of hypertension. And APN could be used in the therapy of the hypertension.