The Protection Of Brain On Cerebral Ischemia Gerontal Patient Of Creatine Phosphate In The Period Of Operation

Objective:To observe the impact of Creatine Phosphate in the period of technique on Cerebral ischemia gerontal patient.Although Cerebullar weight only account body weight 2%,but it receiving Cardiac output 15%.Cerebullar Oxygen and energy have a little reserve,also no post ready blood capillary.Due to these character"High provide","High consume","Low reserve"on Physiology anatomy. Once incur ischemic and deficiency oxygen, furthermore to damage compare other organs. so,It is very important that brain protection compare other organs.Methods:Select gerontal patient with discover arteria vertebralis blood-supply insufficient preoperation cheak 62 examples, ASAⅡ-Ⅲgrade, years of age 55-73,mean age (62±3), Hospital admission force or post ran to divide two group:(Ⅰ) Control group:(Isotonic Na chloride 100ml);(Ⅱ) Creative phosphate therapy group:(1g Creative phosphate+Isotonic Na chloride 100ml),Each group 31 examples.Disseminated sclerosis,traumatic brain injured,autism,dementia praecox,depressive disorder,anxiety disorder,Eating disorder,peripheral nerve and Central netvous system foundation disease,Cardiac disease,Renal disfunction,lung disfunction were deplete preoperative.All examples received premedication with IM Atropine(0.5mg) and Lumina(0.1g) 30 minutes before anesthesia.After preoxygenation,anesthesia was induced by intravenous injection with Midazolam0.03mg/kg,Fentanyl3-4ug/kg,Etomidate0.3mg/kg,Atracurium 0.7-0.8mg/kg.Treacheal intubation (7.0-7.5mm inside diameter endo-reacheal tube). Total IV anesthesia was maintained with Propofol,atracurium and fentanyl depend body weight.The lung were ventilated with oxygen(fraction of inspired oxygen [Fio2]=1) with intermittent positive-pressure ventilation(IPPV),and the ventilator setting was set at a frequency of 10 breaths/min and a tidal volume of 10ml/kg. Therapy group give Creatine phosphate (trade (brand)name)1g dissolve to physiological saline 100ml after anesthesia induce. Therapy group and Control group discern take suction arterial blood string blood gas analysis and ion detemination at before anesthesia,one hour after administer,two hour after administer. Introduction Japanese Olympus1000 hole automatic bioche-mistry analyzer to determin Creatine kinase brain isoenzyme(CK-BB) with be to used specially for quality control(QC) blood serum provid by Shanghai bioengineering company limited at proanaesthesia(h0) one hour after administer,24 hour after administer (h2) suction venous blood.Use humany-amino butyric acid ELISA kit to determiny-amino butyric acid content. Therapy group and Control group discern take suction venous blood at before anesthesia,one hour after administer,two hour after admin-ister.Date are means±SD.Results:The gender age,body weight,Operation time,high blood pressure and so on of two groups no especially at common condition (P>0.05).Compare to control group,blood oxygen partial pressure have a conspicuous heighten after administer in Therapy group (P>0.05) Compared to Preoperative,Phosphocreatine Kinase brain isoenzyme (CK-BB) obviously to heighten in two groups at 24h of postoperative,but compared to control group,decrease obviously to diminish in Therapy group (P<0.05). compared to control group,γ-amino butyric acid level have a conspicuous step up in Therapy group after administer (P<0.05) Ca2+concentration in Therapy group obviously super control group (P<0.05),but Na+,K+ concentration have no marked change (P>0.05)Conclusion:Creatine Phosphate may elevated blood oxygen pressure in Gerontal patient with cerebral ischemia at surround operation. Elevate creatine level related to ATP, or to conserve energy proportion. Suppress excitatory amino acids release,promote y-amino butyric acid release. Promote recovery and exist of casualty corpuscular.