Analysis Of The Risk Factors For Benign Essential Blepharospasm

【Objective】To explore the risk factors of benign essential blepharospasm(BEB)and each factor's intensity.【Methods】Totally 100 patients with BEB including Meige and cranial-cervical without other neurological abnormalities were recuited from the outpatient clinic of Department of Neurology,Peking Uion Medical College Hospital from April 2009 to March 2010 as case group. Patients with atypical features suggesting secondary blepharospasm were excluded.At the same time,100 outpatients diagnosed with idiopathic hemifacial spasm(HFS) and 40 healty controls including spouses of BEB and HFS patients without extrapyramidal diseases or other neurological diseases were recuited from the same outpatient clinic.All the cases and controls were investigated by questionnaires about general conditions, social behavioral factors,environmental factors, phychiatrical factors,genetic factors,previous diseases, with main variances(dwelling,life events,educational level,manual work,pesticides.head or face trauma with and without loss of consciousness, eye diseases,Hamilton anxiety and Hamilton depression scale,obsessive-compulsive symptoms,family history of dystonia and tremor and Pakinsonism, CO intoxication, hypertension,diabetes,thyroid diseases,wine drinking,cigarette smoking,coffee and tea drinking history).The data was analysed by Logistic regression model with the statistical software SPSS 11.5.【Results】Multivariate analysis indicated that eye disease,anxiety and depression were positively related with BEB,whereas coffee drinking had a negative relationship with BEB.【Conclusions】The risk factors of BEB are eye diseases,anxiety and depression.Coffee drinking is protective for BEB.The results suggest that local injury and phychiatrical factors may be more important than genetic factor in the aetiology of BEB.