Effect Of Sijunzi Decoction And Enteral Nutrition On Immune Function In Patients With Critical Diseasse

Objective:TO observes the effect of Si-Jun-Zi Decoction and enteral nutrition on immune function in patients with Critical diseasse, and to explore the profit gas is good for the spleen of the traditional Chinese medicine in clinical treatment danger serious illness application.Methods:In this prospective, sing-blinded, controlled, fourty-eight patients who moves in my courtyard ICU with critical diseasse form June,2009 to March,2010 according to 1:1 proportion were divided into the control group and the study team stochastically, and male 27 examples, female 21 examples, age 28-73 years old. The control group and the study team moves in the ICU24-48 hour later, the life symptom is steady, the homeostasis tends balanced and when the gutless in nutrition contraindication starts the enteral nutrition, treats at the same time the group to pour into Si-Jun-Zi Decoction 200ml by the stomach tube, the treatment course 1 week. After moving in the ICU24 hour and the treatment had finished, before dawn extracted the circumference venous blood, examined the T lymphocyte subgroup separately (CD4+, CD3+, CD4+/CD8+), NK cell activeness, the immunoglobulin (IgA, IgM, IgG), and records the common gastro-intestinal tract complication which in the research period two group of patient intestines the nutrition does not endure (stomach zhu to keep, vomit, to attract, distension of the abdomen, diarrhea by mistake), the lungs fungal infections and the MODS occurrence situation. The measurement material by±s the expression, the group compares uses the T-test, the counting material useX2 examinations, P<0.05 has statistics significance. All statistics use the SPSS17.0 statistics software to carry on.Result:41 examples complete the research, the treatment group 21 examples, the control group 20 examples. Before the research, treats the group and control group's sex constitution compares, the age, APACHEⅡTarget difference non-statistics significances and so on grading, the treatment group and the control group obtains CD4+, CD3+, CD4+/CD8+, NK cell activeness, IgM, IgG, IgA to be at the low horizontal position. Treats 1 week later, the study team and treatment group CD4+, CD3+, CD4+/CD8+, NK cell activeness and IgM, IgG, IgA have the promotion, but treats the group obviously to be higher than the control group (P<0.05), in the intestines the nutrition does not endure the gastro-intestinal tract performance (stomach zhu keeps, vomit, to attract, distension of the abdomen, diarrhea the formation rate treatment group to be lower than the control group by mistake), the treatment group lungs fungus infection percentage and the MODS formation rate is also lower than the control group.Conclusion:Si-Jun-Zi Decoction auxiliary intestines the nutrition support can further improve the danger critically ill patient's immunologic function, optimizes in the intestines the nutrition support effect, enhances in the early intestines the nutrition tolerance, reduces the lungs fungal infections and the MODS formation rate.