| Objective:Rheumatoid arthritis (RA) is an unknown pathogenesis of autoimmune disease. It is more common in middle aged women, pericarditis, etc.). Epidemiological investigation showes that the disease incidence is about 0.32%-0.36 in China. Because of its etiology and pathogenesis is not fully understood, although the treatment of drug and methods is variety, it has yet to complete eradicate the drug, in some ways, the treatment is still exploring. The subject of this reacher is using DAS28 integrate to observe the clinic curative effect and safety of Erteng Tongbi Mixture united with Zheng Qingfengtongning sustained release tablets on acute rheumatoid. In order to finding Chinese medicine in combination to provide objective clinical evidence in acute RA.Methods:By 1987, Society of American College of Rheumatology (ACR) classification criteria for the diagnosis based on randomized controlled side Method.90 patients with rheumatoid arthritis were divided into three groups.30 cases were in treament group and treated with Erteng Tongbi Mixture united with Zheng Qingfengtongning sustained release tablets. Another 60 cases were divded into control group A and control group B. Control group A treated with Erteng Tongbi Mixture. Control B group received Zhengqingfengtongning sustained release tablets treatment. Observation period of 3'Months, to objective evaluation of clinical efficacy.through the observation of patients with DAS-28 score changes. OUTCOME MEASURES:The number of Swelling Expanding joints (SJC), Tender joint count (TJC), General health status (GH), Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Rheumatoid factor (RF); blood count, Liver function (ALT, AST), Renal function (BUN, CREA), The quality of life questionnaire in patients (HAQ questionnaire).At the same time more record occurred during the treatment of adverse reactions.Results:The total effective rate in treatment group was 86.7% and that in the control group A was 76.7%, in control group B was67.9%, and there was no significant difference.The clinical results showed that after treatment the DAS28 scores of three groups decreased, and there was differences (P<0.001). However, the treatment group DAS28 between the two groups points lower than in the control A group and the control B group, there was no significantly different (P< 0.05). Between the control A and the control B,there were no statistically difference(P>0.05).That shows Erteng Tongbi mixture and Zheng qing feng tong ning sustained release tablets either alone or in combination could reduce the acute phase of RA disease activity. And the treatment group better than control group.Improvement in symptoms and signs, three groups of patients before and after treatment the number of joint swelling, tenderness and the number of overall health status had improved, there are differences by statistical tests (P<0.001). Results between the two groups:the treatment group and the control A, B Two groups had significant difference (P<0.05); control A group and control group B than in improving the overall health state of patients with no significant difference (P>0.05), the reduction of the number of joint swelling, tenderness, and improvement in control A number of groups and control groups B significantly different (P<0.05).Indicators in the laboratory, the three groups before and after treatment compared to patients with ESR, CRP, RF were significantly reduced, by the statistical treatment, there are differences (P<0.001). Results between the two groups:the treatment group and the control A, B group was significantly different (P<0.05); control A group and control group B patients in the RF area to improve was no significant difference (P>0.05), the in reduce the ESR, CRP check against the A group and the control B group were significantly different (P<0.05).Improve the quality of life in patients with the treatment group and the control A, B before and after treatment by statistical test, significantly different (P<0.05); but in between the two groups than the control treatment group A, B group (P<0.05), while the control A group and the control B group, there was no significant statistical difference (P>0.05). Three groups compared in terms of drug safety by X2 test, P>0.05, the difference was not statistically significant. Conclusion:1,Erteng Tongbi Mixture and Zhengqingfengtongning sustained release tablets can reduce the acute RA patients with DAS28 score, reducing the number of swollen joints, number of joints with tenderness; improve the overall health status of patients, reduce patient erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor, improve patient quality of life. Their combination is more effective than single drug, shows Erteng Tongbi Mixture and Zhengqingfengtongning sustained release tablets can effectively control the acute phase of RA patients, the combined model as used in clinical medicine.2,Drug safety, the combination of the two drugs adverse reaction than a single application has not increased, indicating the treatment of good safety.
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