Clinical Effects Of Single-dose Parecoxib Sodium Prevents Remifentanil-induced Postoperative Hyperalgesia From General Anesthesia

ObjectiveTo investigate the effects of single-dose parecoxib sodium in preventing remifentanil-induced postoperative hyperalgesia from general anesthesia.MethodsNinety ASAⅠ～Ⅱpatients aged 18-55yr weighing 45-70kg undergoing elective laparoscopic thyroidectomy under general anesthesia were randomly divided into 3 groups(n=30 each) according to the received dose of parecoxib sodium:After intubation, group A received intravenous parecoxib sodium 40mg,group B received intravenous parecoxib sodium 20mg and group C received placebo. Anesthesia was maintained with propofol,remifentanil and atracuronium by target-controlled infusion. At the time of extubation, the depth of sedation and degree of emergence agitation were assessed using Ramsay sedation score (1=fully awake; 6=asleep) and emergence agitation score (0=quiet, cooperative,3=severe agitated) respectively. We record the mean arterial pressure, heart rate, the anaesthesia recovery time, the duration of anesthesia and surgery, the anaesthesia recovery time, the consumptions of opiate, Visual analog scale, the time of postoperative patients require first dose of tramadol and the dosage, the postoperative complications.Results1.Comparison of Ramsay scale, Visual analog scale, agitation, blood pressure and heart rate stability, there was statistically significant difference between three groups at four time points of extubation and after extubation (P<0.05). The patients were better sedated and the degree of emergence agitation was significantly lower in group A than in group C (P<0.05), the blood pressure and heart rate were more stable in group A than in group C (P<0.01)2. Comparison of the latency from the end of surgery to the patients requiring the first dose of tramadol,there was statistically significant difference between three groups (P<0.01),the latency of tramadol injection of group A was the longest, meanwhile, group C was the shortest.3. Comparison of the duration of surgery, duration of anaesthesia, the anaesthesia recovery and extubation time, the consumptions of remifentanil and fentanyl, the postoperative complications, there was no statistically significant difference between groups (P>0.05)Conclusionssingle-dose parecoxib sodium can prevent remifentanil-induced postoperative hyperalgesia from general anesthesia and reduce postoperative agitation.