The Expression Of IGF-I,ER And PR In Postmenopausal Uterine Leiomyoma

Objective:To investigate the expression of insulin-like growth factor-I(IGF-I), estrogen receptor(ER) and progesterone receptor(PR) in postmenopausal uterine leiomyoma and to investigate the pathogenesis of postmenopausal uterine leiomyoma.Methods:95 patients operated for uterine leiomyoma were collected in Shenzhen People's Hospital from 1999 to 2010. Including 26 cases with postmenopausal non-atrophic uterine leiomyoma included Test Group, and 69 cases with proliferative phase of uterine leiomyoma included Control Group. For every case examined the expression of IGF-I, ER and PR in the uterine leiomyoma by immunology histochemical technique. The data was detected through Wilcoxon statistic rank sum test.Results:(1) In leiomyomas of postmenopausal patients, the positive rate of IGF-I is 73.08%, compared with that of 95.65%in the procreation patients group. The expression of IGF-I in leiomyomas of postmenopausal patients was lower than that in leiomyomas of procreation patients(z=3.819, p=0.000). (2) The positive rate of ER is 84.62%in leiomyomas of postmenopausal patients, and it is 50.72%in leiomyomas of procreation patients. The expression of ER in leiomyomas of postmenopausal patients was higher than that in leiomyomas of procreation patients (z=4.1899, p=0.000). (3) The positive rate of PR in leiomyomas of procreation patients is 88.46%, compared with that of 98.55%in the procreation patients group. There was no obvious difference in expression of PR between uterine leiomyoma of postmenopausal patients and of procreation patients (z=1.439, p=0.150).Conclusion:The result suggested that the expression of IGF-I may be association with the postmenopausal uterine leiomyoma growth. The high expression of ER, PR in symptomatic postmenopausal uterine leiomyoma which could raise the sensitiveness to estrogen and progestogen may play a role to sustain uterine leiomyoma growth.