An Analysis Of The Metabolic Correlation Factors In Patients With Type 2 Diabetes Mellitus Complicated With Hyperuricemia

At present, with rapid development of economic, people's living standards rising and changes in diet, the prevalence of hyperuricemia is increasing rapidly.Studies indicated that hyperuricemia was closely correlated with dylipidemia, hypertension, chronic renal disease, metabolic syndrome and so on, except gout.The relationship between type 2 diabetes mellitus complicated with hyperuricemia and metabolic correlation factors, type 2 diabetes mellitus complicated with hyperuricemia and hyperuricemia, are of exploring. We analyzed the medical data of 138 type 2 diabetic complicated with hyperuricemia patients in Endocrinology between July 2009 and December 2009 and checkup data of 146 hyperuricemia persons in our department to study the metabolic correlation factors in type 2 diabetes mellitus complicated with hyperuricemia.Subjects and methodsThe medical data of 138 type2 diabetic complicated with hyperuricemia patients in Endocrinology between July 2009 and December 2009 and checkup data of 146 hyperuricemia persons in our department were selection. The type2 diabetes mellitus complicated with hyperuricemia group (group A) consist of 138 patients, (male 76, female 62), mean age (62.1±9.6), the hyperuricemia group (group B) 146 patients, (male 82, female 64),mean age (60.9±9.7).Physical and laboratory examination:height, weight, waist, hip, TG, TC, HDL-C, LDL-C, UA, Scr, FBG, FINS, HOMA-IR, Ccr, SBP, DBP and PP.The measurement data were reported as (x±s), and statistically analyzed by t test. The enumeration count data were statistically analyzed by x2 test. Stepwise regression was used in statistical analysis of the data by SPSS 16.0. P<0.05 was considered statistically significant.Results1. The comparison in general data between two groups:There were no differences in age, weight and WHR between the two groups (P>0.05). The BMI in group A was higher than group B (P＜0.05).2. The comparison in examination statistics between two groups:the uric acid level, SBP, DBP, PP, LDL-C, FBG, FINS and HOMA-IR SCr in group A were significantly higher than group B (P<0.05), HDL-C and Ccr in group A were significantly lower than group B (P＜0.05).3. The prevalence between two groups:The prevalence of hypergravitation and (or) obesity, abnormal lipid metabolism, hypertension and metabolic syndrome in group A was 79.7%,76.8%,91.3% and 79.7%, respectively. Those in group B were 51.4%, 54.8%,50% and 30.1%, respectively. There were statistical differences between two groups (P<0.01). The prevalence in group A was significantly higher than group B.4. Stepwise regression analysis showed that Ccr, Weight and LDL-C were identified as an independent risk factor for type 2 diabetes mellitus complicated with hyperuricemia. However, Ccr was identified as an independent risk factor for hyperuricemia.Conclusion1. The prevalence of hypergravitation and (or) obesity, abnormal lipid metabolism, hypertension and metabolic syndrome in type 2 diabetes mellitus complicated with hyperuricemia was significantly higher.2. Ccr, Weight and LDL-C were identified as independent risk factors for type 2 diabetes mellitus complicated with hyperuricemia.