The Clinical Study Of Parenteral Nutrition-associated Cholestasis In Preterm Infants

ObjectiveTo determine the risk factors and the prevention measure of parenteral nutrition associated (PNAC) in preterm infants.MethodsThe clinical data of 100preterm infants receiveing parenteral nutrition(PN)for 14 days or above that were collected. The preterm infants were divided into two groups, PNAC or non-PNAC. The risk factors of PNAC were analyzed.ResultsThe incidence of PNAC were 26%. Compared with non-PNAC group, the average gestational age of PNAC group and birth weight was lower; PN duration and birth weight regain time of PNAC group were higher. Duration of PN, fat emulsion dosage, amino acide dosage of PNAC was larger than non-PNAC.ConclusionsThe PNAC risk factors were low gestational age, longer duration of PN, higher energy intake of PN. The prevention and treatment measures should include early enteral feeding and early transition from PN to total enteral nutrition, appropriate energy intake, bifidobacterium and choleretic drugs, reduce the activity of liver enzymes drugs were the important to prevention and treatment of PNAC.