Histopathological Risk Factors For Lymph Node Metastasis In Early Gastric Cancer

Objective:To explore the histopathological predictors for lymph node metastasis in early gastric cancer (EGC) and evaluation the endoscopic therapy for EGC.Methods:Between 2006 and 2009, a total of 214 patients were diagnosed and treated for EGC in the second affiliated hospital of Zhejiang university college of medicine. The study of the association between lymph node metastases and other clinicopathological variables such as age, gender, macroscopic appearance, tumor size, depth of invasion, histopathological type and lymphovascular invasion, was conducted using the binary logistic regression model.Results:There were significant correlations between lymph node metastasis and the size of tumor (OR=2.014,95%CI(1.049-3.865), p=0.035), depth of invasion (OR=7.112,95%CI (2.484-20.362), p<0.001), histopathological type (OR=3.353, 95%CI (1.294-8.690), p=0.013), lymphovascular invasion (OR=2.812,95%CI (1.043-7.583), p=0.041).Conclusion:Tumor size, depth of invasion, histopathological type and lymphovascular invasion were independent predictors of nodal involvement in EGC.