Relationship Between Intramucosal PH And Heart Function In Infants And Children After Cardiopulmonary Bypass

Object:The objective of this study was to discover the general regular change of the intramucosal pH within the initial 72 hours following heart surgery under CPB in infants and children.To discuss the relationship between standard pHi, cardiac index, SvO2 and blood lactate levels. Taken advantage of this indicator, patients were probably to be given the lifesaving interventions that will improve the outcome.Patients and methods:Eighteen infants and children with congenital heart disease after CPB were selected from August 2009 to April 2010 in children's hospital of Zhejiang University. Measurements of PgCO2 were obtained using air tonometry.Cardiac index (CI) calculated by the PiCCO system. Meanwhile, measurements of mixed venous oxygen saturation (SvO2), PCO2 and serum lactate were obtained from blood gas, respectively. Standard pHi was calculated according to fomula (pHi= 7.40-logPtCO2/PaCO2). Results:No patients developed any major postoperative complications.The postoperative course of the patients was satisfactory. Standard pHi descended at first and ascended after T2, and then arrived its peaks at T7. CI desended gradually and ascended after T4, and then arrived its peaks at T7 SvO2 desended gradually and ascended after T3, and then arrived its peaks at T4. Serum lactate descended gradually after CPB.There were significant positive correlations between CI and pHi, SvO2(P<0.05). There was a significant negative correlation between CI and Serum lactate(P<0.05).Conclusion:1. PHi,SvO2 and serum lactate were correlation with CI.2. PHi can reflect earlier changes in cardiac function.