Correlation Between Stress Index And Plasma Catecholamines During Open Heart Surgery With Cardiopulmonary Bypass

ObjectiveTo explore the possibility of continuous noninvasive monitoring stress response for intraoperative patients,we investigated the correlation of stress index with plasma catecholamines in the application of multi-functional combined monitor HXD-1 and supraorbital artery blood flow sensor in open heart surgery during cardiopulmonary bypass,so as to explore the possibility of continuous noninvasive monitor.MethodsTwenty-seven patients undergoing open heart surgery with cardiopulmonary bypass from March to June 2018,Connecting HXD-1 and supraorbital artery blood flow sensor to monitor Stress index(SSI-S)at immediately before cardiopulmonary bypass(CPB)(T1),CPB 5min(T2),CPB 10min(T3),CPB 15min(T4),and CPB(T5).The the blood glucose(Glu),plasma epinephrine(E),norepinephrine(NE)were obtained at five time points.The correlation between SSI-S and biochemical indicators of stress response were calculated using covariance analysis.ResultsThrough covariance analysis,the SSI-S were positively correlated with the plasma concentration of epinephrine,norepinephrine and blood glucose.The correlation coefficients between SSI-S with epinephrine,norepinephrine and blood glucose were 0.69,0.72,0.77,the square of R were 0.79,0.706,0.61,respectively.All P <0.001.ConclusionsSSI-S showed a good correlation with plasma epinephrine,norepinephrine and blood glucose levels in open heart surgery during cardiopulmonary bypass,and may apply to monitor continuous noninvasive monitoring of intraoperative stress response.