Effect Of Thrombus Aspiration And Tirof Iban On Patients With Thrombotic Burden Lesion

Objective: Observe security of using tirofiban hydrochloride,thrombus suction pipe and percutaneous coronary intervention (PCI) methods to treat acute myocardial infarction (AMI) , and study the mechanism supporting the theoretical evidences for clinic application.Methods:Based on the rules of selecting and ejecting experimental samples,collecting 70 AMI and thrombus burden diseases in coronary artery patients proved by coronary artery visualization in department of cardiology of, General Hospital of Da-qing Oil-field during Dec, 2008 to Dec, 2009. After the routine AMI treatment, using tirofiban hydrochloride to treat PCI group and the thrombus aspiration (PT) group & PCI group randomly. The patients of PCI group were treated by PCI, the patients of and PT & PCI group were treated by PCI ally with DiverC.E.. Record the general data, TIMI data, the summation of ST segment elevation,resolution of the sum of ST-segment elevation (sumSTR),Myocardial blush grade (MBG),left ventricular ejection fraction (LVEF),security event and MACE。Results:There is not statistically significant between two groups with data of year, gender, merged hypertension, diabetes mellitus and interference time (P>0.05). The TIMI data is 2.54±0.18 and the other one is 2.01±0.28. Analyzing the data,there is statistically significant between these two groups (P<0.05). There is statistically significant between PCI group (17,68.00%) and PT & PCI group (39 , 86.67%) of MBG3 (P<0.05). Based on LVEF results of electrocardiogram (ECG) there is statistically significant between PCI group(5.11±9.0)and PT & PCI group (56.1±9.2). During hospital staying, The MACE incidence rate of PT & PCI group is more than PCI group, and there no more security events in PCI group.Conclusion:1. It is effective method that thrombus suction ally withⅡb /Ⅲa receptor antagonist treat AMI merged thrombus burden diseases,the blood flow of coronary artery and heart muscle perfusion of dead zone have been improved greatly.2. Thrombus suction ally withⅡb /Ⅲa receptor antagonist method can improve TIMI and MBG grade in IRA of STEMI patients, retrieve the cardiac muscle in extremis and reduce the MACE events.3. Thrombus suction ally withⅡb /Ⅲa receptor antagonist method can improve Left Ventricular Function of acute MI with ST segment elevation patients. And make the Prognosis better.4. There is no severe hemorrhagic complication in treating AMI merged thrombus burden diseases With thrombus suction ally withⅡb /Ⅲa receptor antagonist method. It is the reason that can prove it is secure the therapy of PCI against AMI.