Application Effect Of Thrombus Aspiration Combined With Tirofiban In Elderly Patients Undergoing Emergency PCI

Objective:To discuss the application effect of thrombus aspiration combined with tirofiban in elderly patients with acute myocardial infarction undergoing emergency percutaneous coronary intervention(PCI).Methods: 120 elderly patients with acute myocardial infarction who underwent emergency PCI treatment from February 2011 to February 2014 were enrolled in this study.They were randomly divided into two groups: control group(n = 60)and conventional PCI Surgical treatment;observation group of 60 cases,in the conventional PCI surgery on the basis of thrombectomy combined with tirofiban treatment.The levels of cardiac function,creatine kinase isoenzyme(CK-MB),the postoperative electrocardiogram(PCI),and the postoperative heart rate were measured before and after PCI in 2 groups(P <0.05).3h ST segment depression rate,troponin recovery time,follow-up within 3 months after the adverse cardiovascular events and the incidence of hemorrhagic complications and other indicators.Results:(1)There was no significant difference between the TIMI blood flow grade and the control group before PCI in the observation group(P> 0.05).After PCI operation,the indexes of the patients before and after PCI were There were significant differences between the two groups before and after operation(P <0.05).(LVV)were(43.2 ± 3.0)mm and(43.6 ± 2.9),respectively(P <0.05),and the left ventricular end systolic diameter(LVV)was(31.3 ± 2.2)(51.5 ± 2.1)mm and LVEF were(51.3 ± 4.1)% and(51.1 ± 4.0)%,respectively.There was no significant difference between the two groups(P> 0.05).(2)LVEF was(45.2 ± 3.9)% and(50.8 ± 3.8)%(P <0.05),LVEDD were(47.8 ± 2.7)mm and(44.1 ±)(P <0.05).The level of LVESD was(34.6 ± 2.4)mm and(32.6 ± 2.5)mm(P <0.05)respectively.The LVEF was(1%)in the observation group and the control group(49.7 ± 2.6)mm and(44.3 ± 3.3)mm(P <0.05),respectively,and the LVESD were(39.7 ± 2.3)mm and(50.7 ± 3.6)%(33.1 ± 2.6)mm(P <0.05).There was significant difference between the two groups(P <0.05).(3)The recovery time of troponin in the observation group was(6.01 ± 0.72)d,which was significantly shorter than that in the control group(8.96 ± 0.86)d,the peak of creatine kinase isoenzyme(CK-MB)was(113.25 ± 21.34)mmol / L was significantly lower than that of the control group(188.96 ± 25.78)mmol / L,and the rate of ST segment depression was 91.67% in the observation group at 3 hours after PCI,which was significantly higher than that of the control group(68.33%),the difference of the three indexes Significant,statistically significant(P <0.05).(4)The incidence of adverse cardiovascular events in the observation group was 3.33%,which was significantly lower than that in the control group(16.67%).The difference between the two groups was statistically significant(P <0.05);the incidence of hemorrhagic complications in the observation group and the control group Respectively,5.00% and 8.33%,respectively.There was no significant difference between the two groups(P> 0.05).Conclusion: Thrombectomy combined with tirofiban can not only improve the TIMI blood flow classification,left ventricular function,ST segment drop rate and other related indexes within 3 hours after PCI in elderly patients with acute myocardial infarction.Effectively reduce the incidence of cardiovascular adverse events and hemorrhagic complications,improve the long-term prognosis of patients,showing a good development prospects.