Analysis Of 13 Children With Neuroblastoma

Objective: Neuroblastoma, the most common extracranial solid tumor of childhood, with high degree of malignancy and early metastasis. This study analyzed the clinical data, treatment and therapy of children's NB, so as to improve early diagnosis, improve prognosis and quality of life provide a basis.Methods: By March 2009 to March 2010 13 cases treated in our department clinical data of NB were analyzed retrospectively, summarize the age of onset, clinical manifestations, laboratory tests and related image information, treatment and clinical response to treatment of the group.Results: It's age The group of 13 patients with NB children, age less than 4 years accounted for 92.31%. It's common clinical feature were abdominal distention, ostealgia, fever of unknown origin, etc. It's common signs were abdominal mass, anemia, and skin lumps, etc. The most common primary site of NB was found in abdomen. 11 patients diagnosed were in stage IV, and thgy were all found metastasis at the time of diagnosis, and the most common sites of metastasis were bone marrow and lymph nodes, both of the percentage was 53.85%. 7 cases accompanied with bone metastasis had varying degrees of anemia. 13 cases of NB in children, more than 50% of the time of diagnosis from patients IV tumor markers (including NSE, LDH and serum Ferritin) detect abnormal increases, but it has no significant increase of AKP in patients with bone metastasis. Imaging studies are abnormal, especially in children with primary retroperitoneal, abdominal ultrasound are abnormal, and abdominal CT showed an irregular density, there was high-density calcification in it. 8 cases of children receiving treatment, including 6 cases of children with preoperative chemotherapy, after chemotherapy, their clinical symptoms were improved and the primary tumor was significantly reduced compared with chemotherapy before.Conclusion: Bone marrow examination and pathology were still the most important diagnostic methods in children with NB. Preoperative chemotherapy in children with NB improved chances of surgical complete excision. LDH and Ferritn can be used as supplementary indicators to determine tumor burden before chemotherapy, but they can not be used as effective indicators to determine validity of chemotherapy. And the Ferritin monitoring can be used as secondary indicators to determine whether there is tumor recurrence during chemotherapy. For NB patients with bone metastasis, AKP had no clear diagnosis significance.