Influence Of Thrombocytopenia On Systemic Inflammatorome Response Syndrome

backgrounds and objections:It is well known to us that thrombocytopenia could increase the risk of bleeding. Recently, some research has found that mediators of inflammation and agglutination-fibronolysis system can interact with each other, they can be treated a couple system in a way. Platelet, as an important compound of the couple system, has played an important role in the regulation of mediators of inflammation by the expression of receptor on membrane and release many kinds of mediators. In the research we have brought in 395 patients that treated in ICU. We concern about the platelet count(PLT) and the underline clue between PLT and fatality ratio, Severity of diease.Research Methods:395 patients were included in this study, who choosed in the second clinical hospital of Jilin University from February 2009 to March 2010. All patients were treated in the ICU,189 cases were male,206 cases were female,the mean age is 52.4±14.6 year old. Clinical data collected from the history records, including temperature, blood pressure, heart rate,breath rate, saturation of arterial blood oxygen, pH, Na+, K+, creatinine, hematocrit, leucocyte count, Glasgow evaluation, PLT, therapeutic resul of the first day, third day,seventh day, tenth day. Collecting the prothrombin time, activated partial thromboplastin time of patients who had thrombocytopenia.Results: 1.The patients whose PLT between (80-100)×109/L, the incidence of coagulation disorder is 25.35% (18/71). The patients whose PLT between (50-80)x109/L, the incidence of coagulation disorder is 45.95%(17/37). The patients whose PLT between (0-50)x109/L, the incidence of coagulation disorder is 90.91% (10/11). It is intresting that most of the patients who showed coagulation disorder were prothrombin time longer than normal.2. The mean PLT of patients who were diagnosed systemic inflammatory response syndrome (SIRS) was (106.41±20.04)×109/L, and the incidence of thrombocytopenia is 39.61% (82/207). The mean PLT of non-SIRS patients was (116.90±29.25)×109/L, and the incidence of thrombocytopenia is 19.68% (37/188). The mean PLT and incidence of thrombocytopenia of the patients suffered SIRS and non-SIRS have statistics significant differences.3.The mean PLT of survival patients is(117.78±23.46)×109/L, and the mean acute physiology and chronic health evaluationⅡ(APACHEⅡ) is 15.65±2.46 While the mean PLT of dead patients is (93.08±21.08)×109/L, and the mean APACHEⅡis 19.34±3.14. the PLT and APACHEⅡbetween the survival and dead patients has statistics significant differences (P<0.05). All the patients were will treated, and the PLT and score of APACHEⅡon the first day, third day, seventh day, tenth day showed a great coordination. when the PLT increase, the score of APACHEⅡdropped down.Conclusions:1.Coupled with the decrease of PLT, the incidence of coagulation disorder increase obviously, particularly in The patients who PLT between (0-50)×109/L. It is intresting that most of the coagulation disorder patients showed prothrombin time longer than normal.2.The mean PLT of patients who were diagnosed SIRS was lower than the non-SIRS patients, and the mean score of APACHE II and incidence of thrombocytopenia is higher than the non-SIRS patients.3.The PLT and APACHEⅡbetween the survival and dead patients has statistics significant differences (P<0.05). All the patients were will treated, and the PLT and score of APACHEⅡon the first day, third day,seventh day, tenth day showed a great coordination. when the PLT increase, the score of APACHEⅡdropped down.