To Explore The Clinical Study Of Sentinel Lymph Node Biopsy In The Patients With Breast Cancer

Objectives: To research the method of lymphatic mapping and the meaning of the clinical study of sentinel lymph node biopsy in the patients with breast cancer.Methods: To analize the identification of sentinel lymph node and the influential factors, the one hundred and thirty-two patients with breast cancer were carried out sentinel lymph node biopsy using either methylene blue or 99mTc-DX and methylene blue. The sentinel lymph nodes that were negative firstly while axillary lymph nodes were positive were stained with the multilap continuous slice and immunohistochemical by monoclonal antibody CK-19 . Then modified radical mastectomy and simple breast surgery be carried out.Results: 1. There are 132 cases of patients with sentinel lymph node biopsy, 115 cases of successful detection.The detection rate is 87.1%, a total of 245 sentinel lymph nodes were detected, of which one in 38 people, two in 57 people, three in 15 people, 4 in 5, mean is 2.1. 2,SLN succeed rates were 78.0% and 92.7%,respectively. The accuracy rates of SLN were 94.9% and 98.7% . the false negative were 22.2% and 4.5% in the two groups ,respectively.There are obviously difference between blue dye group and the combination group about success rates(P<0.05).2,The success rate of SLN is irrelevate with the size of primary tumour, tumor location, clinic pathologic types(P>0.05),while the study curve and the age of patients were independent factors significantly correlated with the success rate of SLN in our study (P<0.05).Conclusions: 1.The success rate of SLN in combination group is obviously higher than blue dye group. 2.After the study curve and among the younger patients the identification rate was higher. 3.SLN maybe can predict the axillary lymph node status of the early stage breast cancer. 4. ALND would be replaced by SLN among the patients whose SLN(s) have not tumor metastasis in their early stage breast cancer.