The Expression And Clinical Significance Of RegⅣ Proteinum And Carbodrate Antigen72-4 In Gastric Carcinoma Patients' Serum

Objective:To detect Serum levels of Regâ…£proteinum and Carbodrate antigen72-4 (CA72-4) in the patients with gastric carcinoma; investigate its role in the development of gastric carcinoma and the potential possibility that Regâ…£protein becomes a maker of gastric carcinomaMethods:ELISA quantitative analysis was used to examine the serum levels of Regâ…£protein and CA72-4 in thirty-three cases of gastric carcinoma and twenty innocence gastric disease and twenty-eight healthy controls.Results:Regâ…£protein and CA72-4 levels in serum of the patients with gastric carcinoma were higher than that of the normal people(P<0.05). the serum Regâ…£protein levels were related to the advancement, infiltrating level, lymphatic metastasis and clinical stage of tumor(P<0.05) but not associated with patient's age, sex,size, the degree of tumor differentiation(P>0.05); the serum CA72-4 levels were related to the lymphatic metastasis, advancement,clinical stage, malignant degree,size and prognosis of tumor(P<0.05) but not associated with patient's age, sex, location of tumor (P>0.05); moreover, the Regâ…£protein levels in serum of patients with gastric carcinoma were slenderly related to the CA72-4 levels (r=0.112, P=0.535).Conclusion:The level of Regâ…£protein and CA72-4 in serum of the gastric carcinoma were significantly higher than healthy controls. Them are play important roles in the development, invasion and metastasis of tumor. Regâ…£protein as a secrete protein affects adjacent tumor cell to promote its cleavage and multiplication by paracrine mechanism; CA72-4 is a bioactive compound that tumor related gene and production express abnormally,it expresses never or only slightly in normal tissue and innocence disease. The level of Regâ…£protein in serum acts as an important target molecule in early diagnosis, precaution and therapy of gastric carcinoma, furthermore,positive rate of gastric carcinoma diagnosis is significantly elevated by unitive detecting Serum levels of Regâ…£proteinum and CA72-4.