The Assessment On The Response To The Postmenopausal Osteoporosis Treatment Using HRMRI

Objective Observe the effects of different post-menopausal women with osteoporosis in patients with drug efficacy by MRI measurement of trabecular bone micro-architecture. And explore the feasibility of assessing the clinical effects using HRMRI.Methods Choose Healthy postmenopausal women, by calculating the OSTA score and bone mineral density screening measurement,measured lumbar spine bone mineral density, diagnosed with osteoporosis,38 cases whose age range from 53 to74 were selected and grouped according to duration of menopause, patients were divided into two groups, to do MRI of the right Calcaneus using 3-dimensional gradient echo before taking medication, respectively, 3 months and 6 months re-survey Calcaneus bone mineral density, and do the right Calcaneus MRI.Results1,Treatment resultAll patients were followed up after 6 months, waist, back, leg pain and other symptoms are varying degrees of ease, did not fracture during treatment.2,Image analysis result14 parameters were obtained from processing MRI using proprietary software which designed by Shanghai Jiaotong University. Before treatment, the number of nodes/total area, mean trabecular area, trabecular number, frame length/total area and years since menopause and age was significantly positively correlated, Euler number/total area and years since menopause and age were negatively correlated. Trabecular area/total area of the lumbar spine bone mineral density was positively correlated 2-4, Euler number/total area was negatively correlated with lumbar spine bone mineral density. The trabecular bone parameters of the average area of trabecular bone, trabecular bone area/total area, number of nodes/total area of the node to node connection length/frame length, the total number of trabecular bone, skeleton length/total area after treatment have different degrees of growth in two groups(p<0.05), Euler number/total area is reduced after treatment (p<0.05). Post-menopausal group within 10 years the average area of trabecular bone, trabecular bone area/total area, number of nodes/total area, trabecular number, frame length/total area of the growth rate were higher than 10 years after menopause group (p<0.05), Euler number/total area within the group of 10 post-menopausal decline in more than 10 years after the menopause group.Conclusion1,HRMRI on the efficacy of postmenopausal osteoporosis in the role of evaluation is superior to bone mineral density measurements.2,Compared with less than 10 years after menopause, the treatment of postmenopausal women in 10 years is better.3,HRMRI may be a complement for evaluating the clinic effect of osteoporosis treatment.