Serum Angiopoietin Like Protein 4 Levels In Obstructive Sleep Apnea Hypopnea Syndrome

Objective:The aim of the study was to explore the association between serum Angptl4 and OSAHS severity, and to investigate the role of Angptl4 in OSAHS.Methods:Eighty-five cases examined with polysomnography were intermittently selected from the patients in The First Hospital of Shanxi Medical University and divided in two groups. The test group was OSAHS patients, which had 50 cases. All the patients were diagnosed according to the criteria in the Chinese Journal of Tuberculosis and Respiratory in April of 2002, and the cases caused by non-obesity factors or accompanied severe complications, such as diabetes mellitus, hypertension, cardiovascular or cerebrovascular disease, heart failure, tumor, liver, inflammatory or other chronic disease, use of systemic medication, were eliminated. The control group was healthy people, which had 35 cases. Patients with OSASH and healthy controls, underwent a biochemical analysis to estimate fasting levels of Angptl4 and lipid profile.Results:1.The two groups were matched for age and gender. The Neck circumference, Waist circumference, BMI, Waist-to-hip ratio, TC, TG, LDL-C and Angptl4 level in serum of OSAHS patients was higher than that of the control group(P<0.05). The HDL-C level was lower than the control group(P<0.05).By definition, the AHI of OSAHS Group was higher than that of Healthy Group (p<0.05). Also, minimum and average SO2 during sleep were lower in sleep apneic patients compared to normal controls (p<0.05 respectively), while time spent in SO2 <90% during sleep was significantly greater in OSAHS group (p<0.05).2. TG, LDL-C correlated positively with AHI. After controlling for BMI and age, TG still correlated positively with AHI.3. BMI, neck circumference, waist circumference and waist-to-hip ratio correlated positively with AHI. After controlling for BMI, neck circumference, waist circumference and Waist-to-hip ratio still correlated positively with AHI.4. In OSASH patients, Angpt14 levels correlated positively with neck circumference, waist circumference, AHI, time spent in SO2<90% and triglyceride levels (p<0.05) and negatively with minimum SO2 average SO2 and HDL cholesterol levels (p<0.05,respectively). No association was found, however, between Angpt14 levels and BMI or LDL-C.Conclusion:1.Obstructive sleep apnea is closely associated with obesity. And neck circumference, abdominal girth, waist circumference, waist-to-hip ratio are the risk factors for OSAHS. OSAHS is associated with impaired lipid metabolism. After controlling for BMI and age, TG still correlated positively with AHI. So higher blood triglyceride levels, severe the OSAHS is.2. In OSAHS patients, serum Angpt14 levels are significantly higher than the control group.3. Angpt14 may contribute to the impaired lipid metabolism in OSAHS patients.4. In OSASH patients, Angpt14 levels correlated positively with neck circumference, abdominal girth, waist circumference. It may suggested that Angpt14 of adipose tissue may indeed depend on its location within the body.