Association Of 5-HT1B Receptor Gene G861C Polymorphism With Depression And Paroxetine Treatment Response

Objective To explore the association between 5-HT1B receptor gene G861C polymorphism and depression and to examine the relationship of 5-HT1B receptor gene G861C polymorphism and adverse effect of Paroxetine.Methods The genetype and allele frequencies of 165 depression patients and 160 normal people was analyzed with polymerase chain reaction.145 patients were determined by Paroxetine treatment for 4 weeks and evaluated with Hamilton Rating Scale of Depression (HAMD) in 1,2,4weeks.Drug efficacy was evaluated by calculating the reduced rate.Result There was no significant difference between depressive patients and controls (P>0.05).Grouped by gender, there was no significant difference between depressive patients and controls (P>0.05).Grouped by HAMD degree before treatment,There was significant difference in patients with different genotypes (P<0.05).The degree of depression in patients of GG genotype was higher than other ones.After 4 weeks of paroxetine treatment,HAMD score were dropped.There was significant difference of the reducing score (P<0.05).Patients of GG genotype was more sensitive with the treatment of Paroxetine. According to the reduced rate of HAMD to verify the clinical effectiveness of paroxetine, there was significant difference of the effective power at the end of treatment (P<0.05).The effective power of the patients with CC genotype and C allele was higher than others.Conclusion There was no significant association between the G861C polymophisms of 5-HT1B receptor gene and disorder.5-HT1B receptor geneG861C polymorphism was associated with disease serious degree of depression and dverse effect of Paroxetine.